Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.

Published

Journal Article

A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.

Full Text

Duke Authors

Cited Authors

  • Ritchie, AJ; Cai, F; Smith, NMG; Chen, S; Song, H; Brackenridge, S; Abdool Karim, SS; Korber, BT; McMichael, AJ; Gao, F; Goonetilleke, N

Published Date

  • September 12, 2014

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 69 -

PubMed ID

  • 25212771

Pubmed Central ID

  • 25212771

Electronic International Standard Serial Number (EISSN)

  • 1742-4690

International Standard Serial Number (ISSN)

  • 1742-4690

Digital Object Identifier (DOI)

  • 10.1186/s12977-014-0069-9

Language

  • eng