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Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo.

Publication ,  Journal Article
Viventi, J; Kim, D-H; Vigeland, L; Frechette, ES; Blanco, JA; Kim, Y-S; Avrin, AE; Tiruvadi, VR; Hwang, S-W; Vanleer, AC; Wulsin, DF; Davis, K ...
Published in: Nature neuroscience
November 2011

Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we developed new devices that integrate ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors that are connected using fewer wires. We used this system to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures. We found that seizures may manifest as recurrent spiral waves that propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface devices.

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Published In

Nature neuroscience

DOI

EISSN

1546-1726

ISSN

1097-6256

Publication Date

November 2011

Volume

14

Issue

12

Start / End Page

1599 / 1605

Related Subject Headings

  • Visual Cortex
  • Seizures
  • Photic Stimulation
  • Numerical Analysis, Computer-Assisted
  • Neurology & Neurosurgery
  • Microelectrodes
  • Evoked Potentials, Visual
  • Electronics
  • Electroencephalography
  • Electrodes, Implanted
 

Citation

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Viventi, J., Kim, D.-H., Vigeland, L., Frechette, E. S., Blanco, J. A., Kim, Y.-S., … Litt, B. (2011). Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo. Nature Neuroscience, 14(12), 1599–1605. https://doi.org/10.1038/nn.2973
Viventi, Jonathan, Dae-Hyeong Kim, Leif Vigeland, Eric S. Frechette, Justin A. Blanco, Yun-Soung Kim, Andrew E. Avrin, et al. “Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo.Nature Neuroscience 14, no. 12 (November 2011): 1599–1605. https://doi.org/10.1038/nn.2973.
Viventi J, Kim D-H, Vigeland L, Frechette ES, Blanco JA, Kim Y-S, et al. Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo. Nature neuroscience. 2011 Nov;14(12):1599–605.
Viventi, Jonathan, et al. “Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo.Nature Neuroscience, vol. 14, no. 12, Nov. 2011, pp. 1599–605. Epmc, doi:10.1038/nn.2973.
Viventi J, Kim D-H, Vigeland L, Frechette ES, Blanco JA, Kim Y-S, Avrin AE, Tiruvadi VR, Hwang S-W, Vanleer AC, Wulsin DF, Davis K, Gelber CE, Palmer L, Van der Spiegel J, Wu J, Xiao J, Huang Y, Contreras D, Rogers JA, Litt B. Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo. Nature neuroscience. 2011 Nov;14(12):1599–1605.

Published In

Nature neuroscience

DOI

EISSN

1546-1726

ISSN

1097-6256

Publication Date

November 2011

Volume

14

Issue

12

Start / End Page

1599 / 1605

Related Subject Headings

  • Visual Cortex
  • Seizures
  • Photic Stimulation
  • Numerical Analysis, Computer-Assisted
  • Neurology & Neurosurgery
  • Microelectrodes
  • Evoked Potentials, Visual
  • Electronics
  • Electroencephalography
  • Electrodes, Implanted