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A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings.

Publication ,  Journal Article
Escabí, MA; Read, HL; Viventi, J; Kim, D-H; Higgins, NC; Storace, DA; Liu, ASK; Gifford, AM; Burke, JF; Campisi, M; Kim, Y-S; Avrin, AE ...
Published in: Journal of neurophysiology
September 2014

Our understanding of the large-scale population dynamics of neural activity is limited, in part, by our inability to record simultaneously from large regions of the cortex. Here, we validated the use of a large-scale active microelectrode array that simultaneously records 196 multiplexed micro-electrocortigraphical (μECoG) signals from the cortical surface at a very high density (1,600 electrodes/cm(2)). We compared μECoG measurements in auditory cortex using a custom "active" electrode array to those recorded using a conventional "passive" μECoG array. Both of these array responses were also compared with data recorded via intrinsic optical imaging, which is a standard methodology for recording sound-evoked cortical activity. Custom active μECoG arrays generated more veridical representations of the tonotopic organization of the auditory cortex than current commercially available passive μECoG arrays. Furthermore, the cortical representation could be measured efficiently with the active arrays, requiring as little as 13.5 s of neural data acquisition. Next, we generated spectrotemporal receptive fields from the recorded neural activity on the active μECoG array and identified functional organizational principles comparable to those observed using intrinsic metabolic imaging and single-neuron recordings. This new electrode array technology has the potential for large-scale, temporally precise monitoring and mapping of the cortex, without the use of invasive penetrating electrodes.

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Published In

Journal of neurophysiology

DOI

EISSN

1522-1598

ISSN

0022-3077

Publication Date

September 2014

Volume

112

Issue

6

Start / End Page

1566 / 1583

Related Subject Headings

  • Rats
  • Optical Imaging
  • Neurology & Neurosurgery
  • Microelectrodes
  • Male
  • Evoked Potentials, Auditory
  • Electroencephalography
  • Brain Mapping
  • Auditory Cortex
  • Animals
 

Citation

APA
Chicago
ICMJE
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Escabí, M. A., Read, H. L., Viventi, J., Kim, D.-H., Higgins, N. C., Storace, D. A., … Cohen, Y. E. (2014). A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings. Journal of Neurophysiology, 112(6), 1566–1583. https://doi.org/10.1152/jn.00179.2013
Escabí, Monty A., Heather L. Read, Jonathan Viventi, Dae-Hyeong Kim, Nathan C. Higgins, Douglas A. Storace, Andrew S. K. Liu, et al. “A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings.Journal of Neurophysiology 112, no. 6 (September 2014): 1566–83. https://doi.org/10.1152/jn.00179.2013.
Escabí MA, Read HL, Viventi J, Kim D-H, Higgins NC, Storace DA, et al. A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings. Journal of neurophysiology. 2014 Sep;112(6):1566–83.
Escabí, Monty A., et al. “A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings.Journal of Neurophysiology, vol. 112, no. 6, Sept. 2014, pp. 1566–83. Epmc, doi:10.1152/jn.00179.2013.
Escabí MA, Read HL, Viventi J, Kim D-H, Higgins NC, Storace DA, Liu ASK, Gifford AM, Burke JF, Campisi M, Kim Y-S, Avrin AE, Spiegel Jan VD, Huang Y, Li M, Wu J, Rogers JA, Litt B, Cohen YE. A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings. Journal of neurophysiology. 2014 Sep;112(6):1566–1583.

Published In

Journal of neurophysiology

DOI

EISSN

1522-1598

ISSN

0022-3077

Publication Date

September 2014

Volume

112

Issue

6

Start / End Page

1566 / 1583

Related Subject Headings

  • Rats
  • Optical Imaging
  • Neurology & Neurosurgery
  • Microelectrodes
  • Male
  • Evoked Potentials, Auditory
  • Electroencephalography
  • Brain Mapping
  • Auditory Cortex
  • Animals