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Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level.

Publication ,  Journal Article
Mileto, A; Nelson, RC; Samei, E; Choudhury, KR; Jaffe, TA; Wilson, JM; Marin, D
Published in: AJR Am J Roentgenol
December 2014

OBJECTIVE: The purpose of this article is to investigate the effect of body size on the selection of optimal monochromatic energy level for maximizing the conspicuity of hypervascular liver tumors during late hepatic arterial phase using dual-energy MDCT. MATERIALS AND METHODS: An anthropomorphic liver phantom in three body sizes and iodine-containing inserts simulating low- and high-contrast hypervascular lesions was imaged with dual- and single-energy MDCT at various energy levels (80, 100, 120, and 140 kVp). Dual-energy MDCT was also performed in 48 patients with 114 hypervascular liver tumors; virtual monochromatic images were reconstructed at energy levels from 40 to 140 keV. The effect of body size and lesion iodine concentration on noise and tumor-to-liver contrast-to-noise ratio was compared among different datasets for phantoms and patients. RESULTS: The highest tumor-to-liver contrast-to-noise ratio was noted at 80 kVp for all phantom sizes. On virtual monochromatic images, the minimum noise was noted at 70 keV for small and medium phantoms and at 80 keV for the large phantom. Tumor-to-liver contrast-to-noise ratio was highest at 50 keV for small and medium phantoms and at 60 keV for the large phantom (p<0.0001). Compared with 80-kVp images, an optimal monochromatic energy level yielded a significantly higher (p<0.0001) tumor-to-liver contrast-to-noise ratio for high-contrast lesions in the large body size and for low-contrast lesions in all phantom sizes. In patients, the optimal monochromatic energy level for tumor-to-liver contrast-to-noise ratio increased proportionally along with body size (p<0.0001). CONCLUSION: Selection of the optimal monochromatic energy level for maximizing the conspicuity of hypervascular liver tumors is significantly affected by patient's body size.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

December 2014

Volume

203

Issue

6

Start / End Page

1257 / 1264

Location

United States

Related Subject Headings

  • Signal-To-Noise Ratio
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiography, Dual-Energy Scanned Projection
  • Radiographic Image Interpretation, Computer-Assisted
  • Radiographic Image Enhancement
  • Radiation Dosage
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Neovascularization, Pathologic
 

Citation

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ICMJE
MLA
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Mileto, A., Nelson, R. C., Samei, E., Choudhury, K. R., Jaffe, T. A., Wilson, J. M., & Marin, D. (2014). Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level. AJR Am J Roentgenol, 203(6), 1257–1264. https://doi.org/10.2214/AJR.13.12229
Mileto, Achille, Rendon C. Nelson, Ehsan Samei, Kingshuk Roy Choudhury, Tracy A. Jaffe, Joshua M. Wilson, and Daniele Marin. “Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level.AJR Am J Roentgenol 203, no. 6 (December 2014): 1257–64. https://doi.org/10.2214/AJR.13.12229.
Mileto A, Nelson RC, Samei E, Choudhury KR, Jaffe TA, Wilson JM, et al. Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level. AJR Am J Roentgenol. 2014 Dec;203(6):1257–64.
Mileto, Achille, et al. “Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level.AJR Am J Roentgenol, vol. 203, no. 6, Dec. 2014, pp. 1257–64. Pubmed, doi:10.2214/AJR.13.12229.
Mileto A, Nelson RC, Samei E, Choudhury KR, Jaffe TA, Wilson JM, Marin D. Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level. AJR Am J Roentgenol. 2014 Dec;203(6):1257–1264.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

December 2014

Volume

203

Issue

6

Start / End Page

1257 / 1264

Location

United States

Related Subject Headings

  • Signal-To-Noise Ratio
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiography, Dual-Energy Scanned Projection
  • Radiographic Image Interpretation, Computer-Assisted
  • Radiographic Image Enhancement
  • Radiation Dosage
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Neovascularization, Pathologic