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Metabolic syndrome, diabetes mellitus, or both and cardiovascular risk in outpatients with or at risk for atherothrombosis.

Publication ,  Journal Article
Udell, JA; Steg, PG; Scirica, BM; Eagle, KA; Ohman, EM; Goto, S; Alsheikh-Ali, AA; Porath, A; Corbalan, R; Umez-Eronini, AA; Hoffman, EB ...
Published in: Eur J Prev Cardiol
December 2014

BACKGROUND: The incidence of metabolic syndrome (MetS), diabetes mellitus (DM), and their coexistence is increasing but whether MetS increases cardiovascular risk beyond component risk factors is controversial. DESIGN: We compared the risk of cardiovascular death, myocardial infarction, or stroke among patients with MetS, newly detected DM, established DM, or coexistent MetS and DM in the global REduction of Atherothrombosis for Continued Health (REACH) registry. METHODS: Outpatients with or at risk for atherothrombosis were recruited between 1 December 2003 and 31 December 2004 and followed up to 4 years for cardiovascular events. Risk was compared in patients with or without MetS or DM after adjustment for age, sex, risk factors, vascular disease, fasting blood glucose, therapy, and region. RESULTS: Among 44,548 REACH participants, 17,887 (40%) were without MetS or DM; 6459 had MetS (15%); 12,059 had established DM (27%); 7503 had both (17%); and 640 had newly detected DM (1%). Presence of MetS was not associated with higher cardiovascular events (12.6%, adjusted HR 0.98, 95% CI 0.89-1.08). In addition, once DM was evident, patients with coexistent MetS had similar increased risk (16.1%, adjusted HR 1.33, 95% CI 1.21-1.47) as DM alone (16.7%, adjusted HR 1.36, 95% CI 1.24-1.48). Newly detected DM was associated with increased cardiovascular risk (18.5%, adjusted HR 1.26, 95% CI 1.02-1.57), similar to longstanding DM. MetS was associated with incident DM (adjusted OR 1.94). CONCLUSIONS: In the REACH registry, presence of newly detected DM but not metabolic syndrome was associated with an increased risk of cardiovascular events.

Duke Scholars

Published In

Eur J Prev Cardiol

DOI

EISSN

2047-4881

Publication Date

December 2014

Volume

21

Issue

12

Start / End Page

1531 / 1540

Location

England

Related Subject Headings

  • Thrombosis
  • Stroke
  • Risk Factors
  • Risk Assessment
  • Registries
  • Proportional Hazards Models
  • Prevalence
  • Outpatients
  • Myocardial Infarction
  • Middle Aged
 

Citation

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Udell, J. A., Steg, P. G., Scirica, B. M., Eagle, K. A., Ohman, E. M., Goto, S., … Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators, . (2014). Metabolic syndrome, diabetes mellitus, or both and cardiovascular risk in outpatients with or at risk for atherothrombosis. Eur J Prev Cardiol, 21(12), 1531–1540. https://doi.org/10.1177/2047487313500541
Udell, Jacob A., Ph Gabriel Steg, Benjamin M. Scirica, Kim A. Eagle, E Magnus Ohman, Shinya Goto, Alawi A. Alsheikh-Ali, et al. “Metabolic syndrome, diabetes mellitus, or both and cardiovascular risk in outpatients with or at risk for atherothrombosis.Eur J Prev Cardiol 21, no. 12 (December 2014): 1531–40. https://doi.org/10.1177/2047487313500541.
Udell JA, Steg PG, Scirica BM, Eagle KA, Ohman EM, Goto S, et al. Metabolic syndrome, diabetes mellitus, or both and cardiovascular risk in outpatients with or at risk for atherothrombosis. Eur J Prev Cardiol. 2014 Dec;21(12):1531–40.
Udell, Jacob A., et al. “Metabolic syndrome, diabetes mellitus, or both and cardiovascular risk in outpatients with or at risk for atherothrombosis.Eur J Prev Cardiol, vol. 21, no. 12, Dec. 2014, pp. 1531–40. Pubmed, doi:10.1177/2047487313500541.
Udell JA, Steg PG, Scirica BM, Eagle KA, Ohman EM, Goto S, Alsheikh-Ali AA, Porath A, Corbalan R, Umez-Eronini AA, Hoffman EB, Wilson PWF, Bhatt DL, Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators. Metabolic syndrome, diabetes mellitus, or both and cardiovascular risk in outpatients with or at risk for atherothrombosis. Eur J Prev Cardiol. 2014 Dec;21(12):1531–1540.
Journal cover image

Published In

Eur J Prev Cardiol

DOI

EISSN

2047-4881

Publication Date

December 2014

Volume

21

Issue

12

Start / End Page

1531 / 1540

Location

England

Related Subject Headings

  • Thrombosis
  • Stroke
  • Risk Factors
  • Risk Assessment
  • Registries
  • Proportional Hazards Models
  • Prevalence
  • Outpatients
  • Myocardial Infarction
  • Middle Aged