Hippocampal structural and functional changes associated with electroconvulsive therapy response.

Published online

Journal Article

Previous animal models and structural imaging investigations have linked hippocampal neuroplasticity to electroconvulsive therapy (ECT) response, but the relationship between changes in hippocampal volume and temporal coherence in the context of ECT response is unknown. We hypothesized that ECT response would increase both hippocampal resting-state functional magnetic resonance imaging connectivity and hippocampal volumes. Patients with major depressive disorder (n=19) were scanned before and after the ECT series. Healthy, demographically matched comparisons (n=20) were scanned at one-time interval. Longitudinal changes in functional connectivity of hippocampal regions and volumes of hippocampal subfields were compared with reductions in ratings of depressive symptoms. Right hippocampal connectivity increased (normalized) after the ECT series and correlated with depressive symptom reduction. Similarly, the volumes of the right hippocampal cornu ammonis (CA2/3), dentate gyrus and subiculum regions increased, but the hippocampal subfields were unchanged relative to the comparison group. Connectivity changes were not evident in the left hippocampus, and volume changes were limited to the left CA2/3 subfields. The laterality of the right hippocampal functional connectivity and volume increases may be related to stimulus delivery method, which was predominately right unilateral in this investigation. The findings suggested that increased hippocampal functional connectivity and volumes may be biomarkers for ECT response.

Full Text

Duke Authors

Cited Authors

  • Abbott, CC; Jones, T; Lemke, NT; Gallegos, P; McClintock, SM; Mayer, AR; Bustillo, J; Calhoun, VD

Published Date

  • November 18, 2014

Published In

Volume / Issue

  • 4 /

Start / End Page

  • e483 -

PubMed ID

  • 25405780

Pubmed Central ID

  • 25405780

Electronic International Standard Serial Number (EISSN)

  • 2158-3188

Digital Object Identifier (DOI)

  • 10.1038/tp.2014.124


  • eng

Conference Location

  • United States