Immunotherapy for primary brain tumors: no longer a matter of privilege.

Published

Journal Article (Review)

Immunotherapy for cancer continues to gain both momentum and legitimacy as a rational mode of therapy and a vital treatment component in the emerging era of personalized medicine. Gliomas, and their most malignant form, glioblastoma, remain as a particularly devastating solid tumor for which standard treatment options proffer only modest efficacy and target specificity. Immunotherapy would seem a well-suited choice to address such deficiencies given both the modest inherent immunogenicity of gliomas and the strong desire for treatment specificity within the confines of the toxicity-averse normal brain. This review highlights the caveats and challenges to immunotherapy for primary brain tumors, as well as reviewing modalities that are currently used or are undergoing active investigation. Tumor immunosuppressive countermeasures, peculiarities of central nervous system immune access, and opportunities for rational treatment design are discussed.

Full Text

Duke Authors

Cited Authors

  • Fecci, PE; Heimberger, AB; Sampson, JH

Published Date

  • November 15, 2014

Published In

Volume / Issue

  • 20 / 22

Start / End Page

  • 5620 - 5629

PubMed ID

  • 25398845

Pubmed Central ID

  • 25398845

International Standard Serial Number (ISSN)

  • 1078-0432

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-14-0832

Language

  • eng

Conference Location

  • United States