A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.

Journal Article (Journal Article)

Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (SNP), rs6318 on the HTR2C gene located on the X-chromosome, is associated with hypothalamic-pituitary-adrenal axis response to a laboratory stress recall task. The present paper reports a validation of the cortisol response to stress in a second, independent sample. The study population consisted of 60 adult participants (73.3% males). Consistent with our prior findings, compared to Cys23 G allele carriers, persons homozygous for the Ser23C allele had a significantly greater average cortisol response (p=0.007) and area under the curve (p=0.021) over the course of an emotional stress recall protocol. Also parallel to our prior report, the change in cortisol from baseline to the average during the stress protocol was roughly twice as large among Ser23C homozygotes than among persons with Cys23 G. These findings validate our initial observation of association between rs6318 and cortisol response to an acute stressor, and extend the results to include females.

Full Text

Duke Authors

Cited Authors

  • Brummett, BH; Babyak, MA; Kuhn, CM; Siegler, IC; Williams, RB

Published Date

  • December 2014

Published In

Volume / Issue

  • 103 /

Start / End Page

  • 317 - 321

PubMed ID

  • 25457638

Pubmed Central ID

  • PMC4258145

Electronic International Standard Serial Number (EISSN)

  • 1873-6246

Digital Object Identifier (DOI)

  • 10.1016/j.biopsycho.2014.10.006


  • eng

Conference Location

  • Netherlands