SnapShot: Mammalian Sirtuins.


Journal Article

The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, and biological functions. This SnapShot provides an overview of these properties, with an emphasis on their relevance to aging.

Full Text

Duke Authors

Cited Authors

  • Anderson, KA; Green, MF; Huynh, FK; Wagner, GR; Hirschey, MD

Published Date

  • November 2014

Published In

Volume / Issue

  • 159 / 4

Start / End Page

  • 956 - 956.e1

PubMed ID

  • 25417168

Pubmed Central ID

  • 25417168

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2014.10.045


  • eng