Epidemiology of methicillin-resistant Staphylococcus aureus pneumonia in community hospitals.

Journal Article (Journal Article;Multicenter Study)

OBJECTIVE: Describe the epidemiology of healthcare-related (ie, healthcare-associated and hospital-acquired) pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients in community hospitals. DESIGN: Retrospective cohort study. SETTING: Twenty-four community hospitals in the southeastern United States affiliated with the Duke Infection Control Outreach Network (median size, 211 beds; range, 103-658 beds). METHODS: Adult patients with healthcare-related MRSA pneumonia admitted to study hospitals from January 1, 2008, to December 31, 2012, were identified using surveillance data. Seasonal and annual incidence rates (cases per 100,000 patient-days) were estimated using generalized estimating equation models. Characteristics of community-onset and hospital-onset cases were compared. RESULTS: A total of 1,048 cases of healthcare-related pneumonia due to MRSA were observed during 5,863,941 patient-days. The annual incidence rate of healthcare-related MRSA pneumonia increased from 11.3 cases per 100,000 patient-days (95% confidence interval [CI], 6.8-18.7) in 2008 to 15.5 cases per 100,000 patient-days (95% CI, 8.4-28.5) in 2012 (P = .055). The incidence rate was highest in winter months and lowest in summer months (15.4 vs 11.1 cases per 100,000 patient-days; incidence rate ratio, 1.39 [95% CI, 1.06-1.82]; P = .016). A total of 814 cases (77.7%) were community-onset healthcare-associated pneumonia cases; only 49 cases (4.7%) were ventilator-associated cases. Of 811 patients whose disposition was known, 240 (29.6%) died during hospitalization or were discharged to hospice. CONCLUSIONS: From 2008 through 2012, the incidence of healthcare-related MRSA pneumonia among patients who were admitted to a large network of community hospitals increased, despite the decreasing incidence of invasive MRSA infections nationwide. Additional study is warranted to evaluate trends in this important and potentially modifiable public health problem.

Full Text

Duke Authors

Cited Authors

  • Lewis, SS; Walker, VJ; Lee, MS; Chen, L; Moehring, RW; Cox, CE; Sexton, DJ; Anderson, DJ

Published Date

  • December 2014

Published In

Volume / Issue

  • 35 / 12

Start / End Page

  • 1452 - 1457

PubMed ID

  • 25419766

Pubmed Central ID

  • PMC4408547

Electronic International Standard Serial Number (EISSN)

  • 1559-6834

Digital Object Identifier (DOI)

  • 10.1086/678594


  • eng

Conference Location

  • United States