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Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis.

Publication ,  Journal Article
Williams, DC; Turi, JL; Hornik, CP; Bonadonna, DK; Williford, WL; Walczak, RJ; Watt, KM; Cheifetz, IM
Published in: ASAIO J
2015

Hemolysis can occur as a consequence of extracorporeal membrane oxygenation (ECMO) and is associated with increased mortality and morbidity. Shear stress generated by flow through the circuit and oxygenator is believed to cause ECMO-induced hemolysis. We hypothesize that either a smaller dimension oxygenator or an in-line hemofilter will increase ECMO-associated hemolysis. Circuits were configured with a Quadrox-D Adult oxygenator (surface area 1.8 m), Quadrox-iD Pediatric oxygenator (surface area 0.8 m), or Quadrox-D Adult oxygenator with an in-line hemofilter (N = 4) and ran for 6 hours. Samples were collected hourly from the ECMO circuit and a time-based hemolysis control. Plasma hemoglobin levels were assayed. Circuit-induced hemolysis at each time point was defined as the change in plasma hemoglobin standardized to the time-based hemolysis control. Plasma hemoglobin increased with the use of the smaller dimension pediatric oxygenator as compared with the adult oxygenator when controlling for ECMO run time (p = 0.02). Furthermore, there was a greater pressure gradient with the smaller dimension pediatric oxygenator (p < 0.05). Plasma hemoglobin did not change with the addition of the in-line hemofilter. The use of a smaller dimension pediatric oxygenator resulted in greater hemolysis and a higher pressure gradient. This may indicate that the increased shear forces augment ECMO-induced hemolysis.

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Published In

ASAIO J

DOI

EISSN

1538-943X

Publication Date

2015

Volume

61

Issue

2

Start / End Page

190 / 195

Location

United States

Related Subject Headings

  • Pressure
  • Plasma
  • Oxygenators, Membrane
  • In Vitro Techniques
  • Humans
  • Hemolysis
  • Hemoglobins
  • Hemofiltration
  • Extracorporeal Membrane Oxygenation
  • Equipment Design
 

Citation

APA
Chicago
ICMJE
MLA
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Williams, D. C., Turi, J. L., Hornik, C. P., Bonadonna, D. K., Williford, W. L., Walczak, R. J., … Cheifetz, I. M. (2015). Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis. ASAIO J, 61(2), 190–195. https://doi.org/10.1097/MAT.0000000000000173
Williams, Duane C., Jennifer L. Turi, Christoph P. Hornik, Desiree K. Bonadonna, Walter L. Williford, Richard J. Walczak, Kevin M. Watt, and Ira M. Cheifetz. “Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis.ASAIO J 61, no. 2 (2015): 190–95. https://doi.org/10.1097/MAT.0000000000000173.
Williams DC, Turi JL, Hornik CP, Bonadonna DK, Williford WL, Walczak RJ, et al. Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis. ASAIO J. 2015;61(2):190–5.
Williams, Duane C., et al. “Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis.ASAIO J, vol. 61, no. 2, 2015, pp. 190–95. Pubmed, doi:10.1097/MAT.0000000000000173.
Williams DC, Turi JL, Hornik CP, Bonadonna DK, Williford WL, Walczak RJ, Watt KM, Cheifetz IM. Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis. ASAIO J. 2015;61(2):190–195.

Published In

ASAIO J

DOI

EISSN

1538-943X

Publication Date

2015

Volume

61

Issue

2

Start / End Page

190 / 195

Location

United States

Related Subject Headings

  • Pressure
  • Plasma
  • Oxygenators, Membrane
  • In Vitro Techniques
  • Humans
  • Hemolysis
  • Hemoglobins
  • Hemofiltration
  • Extracorporeal Membrane Oxygenation
  • Equipment Design