Carbohydrate intake, glycemic index and prostate cancer risk.

Journal Article (Journal Article)

BACKGROUND: Reported associations between dietary carbohydrate and prostate cancer (PC) risk are poorly characterized by race. METHODS: We analyzed the association between carbohydrate intake, glycemic index (GI), and PC risk in a study of white (N = 262) and black (N = 168) veterans at the Durham VA Hospital. Cases were 156 men with biopsy-confirmed PC and controls (N = 274) had a PSA test but were not recommended for biopsy. Diet was assessed before biopsy with a self-administered food frequency questionnaire. Logistic regression models were used to estimate PC risk. RESULTS: In multivariable analyzes, higher carbohydrate intake, measured as percent of energy from carbohydrates, was associated with reduced PC risk (3rd vs. 1st tertile, OR = 0.41, 95% CI 0.21-0.81, P = 0.010), though this only reached significance in white men (p-trend = 0.029). GI was unrelated to PC risk among all men, but suggestively linked with reduced PC risk in white men (p-trend = 0.066) and increased PC risk in black men (p-trend = 0.172), however, the associations were not significant. Fiber intake was not associated with PC risk (all p-trends > 0.55). Higher carbohydrate intake was associated with reduced risk of high-grade (p-trend = 0.016), but not low-grade PC (p-trend = 0.593). CONCLUSION: Higher carbohydrate intake may be associated with reduced risk of overall and high-grade PC. Future larger studies are needed to confirm these findings.

Full Text

Duke Authors

Cited Authors

  • Vidal, AC; Williams, CD; Allott, EH; Howard, LE; Grant, DJ; McPhail, M; Sourbeer, KN; Hwa, LP; Boffetta, P; Hoyo, C; Freedland, SJ

Published Date

  • March 1, 2015

Published In

Volume / Issue

  • 75 / 4

Start / End Page

  • 430 - 439

PubMed ID

  • 25417840

Pubmed Central ID

  • PMC4293225

Electronic International Standard Serial Number (EISSN)

  • 1097-0045

Digital Object Identifier (DOI)

  • 10.1002/pros.22929


  • eng

Conference Location

  • United States