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Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

Publication ,  Journal Article
He, M; Xu, M; Zhang, B; Liang, J; Chen, P; Lee, J-Y; Johnson, TA; Li, H; Yang, X; Dai, J; Liang, L; Gui, L; Qi, Q; Huang, J; Li, Y; Cai, Q ...
Published in: Hum Mol Genet
March 15, 2015

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.

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Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

March 15, 2015

Volume

24

Issue

6

Start / End Page

1791 / 1800

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Protein Tyrosine Phosphatases
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Metabolic Networks and Pathways
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
 

Citation

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He, M., Xu, M., Zhang, B., Liang, J., Chen, P., Lee, J.-Y., … Qi, L. (2015). Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet, 24(6), 1791–1800. https://doi.org/10.1093/hmg/ddu583
He, Meian, Min Xu, Ben Zhang, Jun Liang, Peng Chen, Jong-Young Lee, Todd A. Johnson, et al. “Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.Hum Mol Genet 24, no. 6 (March 15, 2015): 1791–1800. https://doi.org/10.1093/hmg/ddu583.
He M, Xu M, Zhang B, Liang J, Chen P, Lee J-Y, et al. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet. 2015 Mar 15;24(6):1791–800.
He, Meian, et al. “Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.Hum Mol Genet, vol. 24, no. 6, Mar. 2015, pp. 1791–800. Pubmed, doi:10.1093/hmg/ddu583.
He M, Xu M, Zhang B, Liang J, Chen P, Lee J-Y, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng C-Y, Cho M-C, Cho YS, Chu M, Cui B, Gao Y-T, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Hwang J-Y, Ikram MK, Jin G, Kang D-H, Khor CC, Kim B-J, Kim HT, Kubo M, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT-H, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang Y-B, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han B-G, Shu X-O, Tai ES, Wu T, Qi L. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet. 2015 Mar 15;24(6):1791–1800.
Journal cover image

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

March 15, 2015

Volume

24

Issue

6

Start / End Page

1791 / 1800

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Protein Tyrosine Phosphatases
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Metabolic Networks and Pathways
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity