Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy.

Other Article (Journal Article)

This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection.

Full Text

Duke Authors

Cited Authors

  • Montefiori, DC

Published Date

  • 2014

Published In

Volume / Issue

  • 10 / 8

Start / End Page

  • 2507 - 2511

PubMed ID

  • 25424964

Electronic International Standard Serial Number (EISSN)

  • 2164-554X

Digital Object Identifier (DOI)

  • 10.4161/hv.28950


  • eng

Conference Location

  • United States