Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy.

Other Article (Journal Article)

This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection.

Full Text

Duke Authors

Montefiori, David Charles

Cited Authors

Montefiori, DC

Published Date

2014

Published In

Hum Vaccin Immunother

Volume / Issue

10 / 8

Start / End Page

2507 - 2511

PubMed ID

25424964

Electronic International Standard Serial Number (EISSN)

2164-554X

Digital Object Identifier (DOI)

10.4161/hv.28950

Language

eng

Conference Location

United States