Levothyroxine improves subjective sleepiness in a euthyroid patient with narcolepsy without cataplexy.

Journal Article (Journal Article)

OBJECTIVE: We discuss the use of levothyroxine for excessive daytime sleepiness (EDS) and prolonged nocturnal sleep time in a euthyroid patient with narcolepsy. METHODS: After failure of first-line narcolepsy treatments, a 48-year-old female began levothyroxine (25 mcg/day). After 12 weeks of treatment, the patient was evaluated for improvement in total sleep time and subjective daytime sleepiness assessed by Epworth Sleepiness Scale (ESS). RESULTS: At baseline, ESS score was 16 and total sleep time averaged 16 h/day. After 12 weeks, ESS was 13 and reported total sleep time was 13 h/day. CONCLUSIONS: Levothyroxine improved EDS and total sleep time in a euthyroid patient with narcolepsy without cataplexy after 12 weeks without side effects.

Full Text

Duke Authors

Cited Authors

  • Sobol, DL; Spector, AR

Published Date

  • November 15, 2014

Published In

Volume / Issue

  • 10 / 11

Start / End Page

  • 1231 - 1232

PubMed ID

  • 25325591

Pubmed Central ID

  • PMC4224725

Electronic International Standard Serial Number (EISSN)

  • 1550-9397

Digital Object Identifier (DOI)

  • 10.5664/jcsm.4210


  • eng

Conference Location

  • United States