A single pipeline embolization device is sufficient for treatment of intracranial aneurysms.
Journal Article (Journal Article)
BACKGROUND AND PURPOSE: The Pipeline Embolization Device has emerged as an important treatment option for intracranial aneurysms. The number of devices needed to treat an aneurysm is uncertain and is the subject of vigorous debate. The purpose of this study was to compare rates of complications, aneurysm occlusion, and outcome in patients treated with a single-versus-multiple Pipeline Embolization Devices. MATERIAL AND METHODS: One hundred seventy-eight patients were treated with the Pipeline Embolization Device at our institution. Patients were divided into 2 groups: a single-device group (n = 126) and a multiple-device group (n = 52). RESULTS: There was no statistically significant difference between the 2 groups with respect to baseline characteristics except for age and aneurysm size (higher with multiple Pipeline Embolization Devices). Complications occurred more frequently with multiple (15%) versus a single device (5%, P = .03). In multivariate analysis, the use of multiple devices independently predicted complications. A similar proportion of patients achieved adequate aneurysm obliteration at follow-up in the single-device (84%) and the multiple-device groups (87%, P = .8). In multivariate analysis, age and follow-up time predicted obliteration. At follow-up, a significantly higher proportion of patients treated with a single device (97%) achieved a favorable outcome compared with those treated with multiple devices (89%, P = .03). In multivariate analysis, there was a strong trend for the use of a single device to predict favorable outcomes (P = .06). CONCLUSIONS: Treatment with a single Pipeline Embolization Device provides similar occlusion rates with less complications and better overall outcomes. These findings suggest that a single Pipeline Embolization Device is sufficient for treatment of most intracranial aneurysms.
Full Text
Duke Authors
Cited Authors
- Chalouhi, N; Tjoumakaris, S; Phillips, JLH; Starke, RM; Hasan, D; Wu, C; Zanaty, M; Kung, D; Gonzalez, LF; Rosenwasser, R; Jabbour, P
Published Date
- August 2014
Published In
Volume / Issue
- 35 / 8
Start / End Page
- 1562 - 1566
PubMed ID
- 24788125
Pubmed Central ID
- PMC7964452
Electronic International Standard Serial Number (EISSN)
- 1936-959X
Digital Object Identifier (DOI)
- 10.3174/ajnr.A3957
Language
- eng
Conference Location
- United States