Endovascular management of cerebral vasospasm following aneurysm rupture: outcomes and predictors in 116 patients.

Journal Article

OBJECTIVE: To retrospectively assess the safety and efficacy of endovascular treatment of cerebral vasospasm with different modalities and assess predictors of outcome. METHODS: Endovascular treatment was indicated in the event of neurological deterioration refractory to medical therapy. Data were collected for 116 patients treated at our institution. RESULTS: Vasospasm was treated with balloon angioplasty in 52.6%, intra-arterial nicardipine infusion in 19.8%, or both in 27.6%. Angiographic vasospasm was reversed in all but 4 (96.6%) patients. The complication rate was 0.9%. Twenty patients (17.2%) had incipient pre-procedure hypodensities; 3 (15%) hypodensities were reversed and neurological improvement occurred in 60% of these patients. Retreatment was required in 22 (19%) patients. Higher Hunt and Hess grades and treatment with nicardipine alone predicted retreatment. Neurological improvement was noted in 82%. Male gender, pre-procedure hypodensities, and posterior communicating artery aneurysm location negatively predicted neurological recovery. Favorable outcomes were noted in 73%. Higher Hunt and Hess grades, pre-procedure hypodensities, posterior circulation aneurysms, and no neurological recovery predicted poor outcome. CONCLUSION: Endovascular therapy for vasospasm has an excellent safety-efficacy profile. Balloon angioplasty and nicardipine are equally effective but effects of nicardipine are less durable. Patients with incipient pre-procedure hypodensities benefit from endovascular intervention and should probably not be excluded from treatment.

Full Text

Duke Authors

Cited Authors

  • Chalouhi, N; Tjoumakaris, S; Thakkar, V; Theofanis, T; Hammer, C; Hasan, D; Starke, RM; Wu, C; Gonzalez, LF; Rosenwasser, R; Jabbour, P

Published Date

  • March 2014

Published In

Volume / Issue

  • 118 /

Start / End Page

  • 26 - 31

PubMed ID

  • 24529225

Electronic International Standard Serial Number (EISSN)

  • 1872-6968

International Standard Serial Number (ISSN)

  • 0303-8467

Digital Object Identifier (DOI)

  • 10.1016/j.clineuro.2013.12.012

Language

  • eng