Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture.

Journal Article (Journal Article;Review)

Smoking is an established risk factor for subarachnoid hemorrhage yet the underlying mechanisms are largely unknown. Recent data has implicated a role of inflammation in the development of cerebral aneurysms. Inflammation accompanying cigarette smoke exposure may thus be a critical pathway underlying the development, progression, and rupture of cerebral aneurysms. Various constituents of the inflammatory response appear to be involved including adhesion molecules, cytokines, reactive oxygen species, leukocytes, matrix metalloproteinases, and vascular smooth muscle cells. Characterization of the molecular basis of the inflammatory response accompanying cigarette smoke exposure will provide a rational approach for future targeted therapy. In this paper, we review the current body of knowledge implicating cigarette smoke-induced inflammation in cerebral aneurysm formation/rupture and attempt to highlight important avenues for future investigation.

Full Text

Duke Authors

Cited Authors

  • Chalouhi, N; Ali, MS; Starke, RM; Jabbour, PM; Tjoumakaris, SI; Gonzalez, LF; Rosenwasser, RH; Koch, WJ; Dumont, AS

Published Date

  • 2012

Published In

Volume / Issue

  • 2012 /

Start / End Page

  • 271582 -

PubMed ID

  • 23316103

Pubmed Central ID

  • PMC3532877

Electronic International Standard Serial Number (EISSN)

  • 1466-1861

Digital Object Identifier (DOI)

  • 10.1155/2012/271582


  • eng

Conference Location

  • United States