Analysis of nonmodifiable risk factors for intracranial aneurysm rupture in a large, retrospective cohort.


Journal Article

BACKGROUND: The risk factors predictive of intracranial aneurysm rupture remain incompletely defined. OBJECTIVE: To examine the association between various nonmodifiable risk factors and aneurysm rupture in a large cohort of patients evaluated at a single institution. METHODS: A retrospective analysis of patients admitted to a cerebrovascular facility between January 2006 and 2010 with a primary diagnosis of cerebral aneurysm. Aneurysms were divided into 2 groups: unruptured or ruptured. The dome diameter, aspect ratio (AR), location, sidedness, neck morphology, and multiplicity were entered into a central database. A full model was constructed, and a systematic removal of the least significant variables was performed in a sequential fashion until only those variables reaching significance remained. RESULTS: We identified 2347 patients harboring 5134 individual aneurysms, of which 34.90% were ruptured and 65.09% were unruptured. On admission, 25.89% of aneurysms with a dome diameter <10 mm and 58.33% of aneurysms with a dome >10 mm were ruptured (P < .001). Of aneurysms with an AR >1.6, 52.44% presented following a rupture (P < .001). The highest incidence of rupture (69.21%) was observed in aneurysms with an AR >1.6, dome diameter <10 mm, and a deviated neck. Deviated neck-type aneurysms had a significantly greater incidence of rupture than classical neck-type aneurysms (P < .001). CONCLUSION: An AR >1.6, dome diameter >10 mm, a deviated neck, and right-sidedness are independently associated with aneurysm rupture.

Full Text

Duke Authors

Cited Authors

  • Amenta, PS; Yadla, S; Campbell, PG; Maltenfort, MG; Dey, S; Ghosh, S; Ali, MS; Jallo, JI; Tjoumakaris, SI; Gonzalez, LF; Dumont, AS; Rosenwasser, RH; Jabbour, PM

Published Date

  • March 2012

Published In

Volume / Issue

  • 70 / 3

Start / End Page

  • 693 - 699

PubMed ID

  • 21904261

Pubmed Central ID

  • 21904261

Electronic International Standard Serial Number (EISSN)

  • 1524-4040

Digital Object Identifier (DOI)

  • 10.1227/NEU.0b013e3182354d68


  • eng

Conference Location

  • United States