Regulation of appetite to treat obesity.


Journal Article (Review)

Obesity has escalated into a pandemic over the past few decades. In turn, research efforts have sought to elucidate the molecular mechanisms underlying the regulation of energy balance. A host of endogenous mediators regulate appetite and metabolism, and thereby control both short- and long-term energy balance. These mediators, which include gut, pancreatic and adipose neuropeptides, have been targeted in the development of anti-obesity pharmacotherapy, with the goal of amplifying anorexigenic and lipolytic signaling or blocking orexigenic and lipogenic signaling. This article presents the efficacy and safety of these anti-obesity drugs.

Full Text

Duke Authors

Cited Authors

  • Kim, GW; Lin, JE; Valentino, MA; Colon-Gonzalez, F; Waldman, SA

Published Date

  • March 2011

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 243 - 259

PubMed ID

  • 21666781

Pubmed Central ID

  • 21666781

Electronic International Standard Serial Number (EISSN)

  • 1751-2441

Digital Object Identifier (DOI)

  • 10.1586/ecp.11.3


  • eng

Conference Location

  • England