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Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort.

Publication ,  Journal Article
Moghekar, A; Goh, J; Li, M; Albert, M; O'Brien, RJ
Published in: Arch Neurol
February 2012

OBJECTIVE: To determine whether cerebrospinal fluid (CSF) biomarkers for Alzheimer disease fluctuate significantly over time in a cohort of older, mildly symptomatic individuals. DESIGN: Biomarker validation in a clinical cohort. SETTING: University hospital inpatient unit. PARTICIPANTS: Ten patients admitted for CSF drainage for diagnostic purposes. MAIN OUTCOME MEASURES: The CSF levels of Aβ1-40, Aβ1-42, tau, and phosphorylated tau on threonine 181 (p-tau(181)) were measured every 6 hours for 24 or 36 hours. RESULTS: The mean coefficient of variation values for each biomarker assessed in our 10 patients were 5.5% (95% CI, 3.8%-10.0%) for Aβ1-42, 12.2% (9.0%-24.2%) for Aβ1-40, 8.2% (5.7%-15.1%) for total tau, and 11.9% (8.5%-23.0%) for p-tau(181). These values are only slightly higher than the variability in the assay. In addition, no significant circadian fluctuation in any Alzheimer disease biomarker was observed given the limitations of our sampling frequency. CONCLUSION: In a cohort of elderly patients, little fluctuation in the levels of important Alzheimer disease biomarkers in lumbar CSF is seen as a function of time.

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Published In

Arch Neurol

DOI

EISSN

1538-3687

Publication Date

February 2012

Volume

69

Issue

2

Start / End Page

246 / 250

Location

United States

Related Subject Headings

  • tau Proteins
  • Reproducibility of Results
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Gait Disorders, Neurologic
  • Female
  • Cohort Studies
 

Citation

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Moghekar, A., Goh, J., Li, M., Albert, M., & O’Brien, R. J. (2012). Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort. Arch Neurol, 69(2), 246–250. https://doi.org/10.1001/archneurol.2011.732
Moghekar, Abhay, Joshua Goh, Ming Li, Marilyn Albert, and Richard J. O’Brien. “Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort.Arch Neurol 69, no. 2 (February 2012): 246–50. https://doi.org/10.1001/archneurol.2011.732.
Moghekar A, Goh J, Li M, Albert M, O’Brien RJ. Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort. Arch Neurol. 2012 Feb;69(2):246–50.
Moghekar, Abhay, et al. “Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort.Arch Neurol, vol. 69, no. 2, Feb. 2012, pp. 246–50. Pubmed, doi:10.1001/archneurol.2011.732.
Moghekar A, Goh J, Li M, Albert M, O’Brien RJ. Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort. Arch Neurol. 2012 Feb;69(2):246–250.

Published In

Arch Neurol

DOI

EISSN

1538-3687

Publication Date

February 2012

Volume

69

Issue

2

Start / End Page

246 / 250

Location

United States

Related Subject Headings

  • tau Proteins
  • Reproducibility of Results
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Gait Disorders, Neurologic
  • Female
  • Cohort Studies