Cultured motor neurons possess calcium-permeable AMPA/kainate receptors.

Published

Journal Article

We examined the biology of AMPA/kainate-induced motor neuron degeneration using dissociated spinal cord cultures and motor neuron-specific antibodies which enable characterization of individual motor neurons in culture. Cobalt, which is thought to pass through Ca2+-permeable AMPA/kainate receptors following kainate exposure, labeled motor neurons in spinal cord cultures. The analysis of AMPA subunit distribution in dissociated motor neurons revealed a unique pattern of glutamate receptor (GluR) subunits in those cells; the GluR1 subunit was found in all spinal cord neurons, but the GluR2 subunit was not found in identified dissociated motor neurons. These data suggest that selective sensitivity of motor neurons to non-NMDA receptor activation is due, at least in part, to the presence of Ca2+-permeable AMPA/kainate receptors.

Full Text

Duke Authors

Cited Authors

  • Bar-Peled, O; O'Brien, RJ; Morrison, JH; Rothstein, JD

Published Date

  • March 17, 1999

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 855 - 859

PubMed ID

  • 10208560

Pubmed Central ID

  • 10208560

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199903170-00034

Language

  • eng

Conference Location

  • England