Molecular mechanisms of glutamate receptor clustering at excitatory synapses.

Journal Article (Review)

The targeting of AMPA- and NMDA-type glutamate receptors to synapses in the central nervous system is essential for efficient excitatory synaptic transmission. Recent studies have indicated that protein-protein interactions of these receptors with synaptic proteins that contain PDZ domains are crucial for receptor targeting. NMDA receptors have been found to bind to the PSD-95 family of proteins, whereas AMPA receptors interact with the PDZ-domain-containing protein GRIP (glutamate receptor interacting protein). PSD-95 and GRIP contain multiple PDZ domains as well as other protein-protein interaction motifs that help to form large macromolecular complexes that may be important for the formation and plasticity of synapses.

Full Text

Duke Authors

Cited Authors

  • O'Brien, RJ; Lau, LF; Huganir, RL

Published Date

  • June 1998

Published In

Volume / Issue

  • 8 / 3

Start / End Page

  • 364 - 369

PubMed ID

  • 9687358

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

International Standard Serial Number (ISSN)

  • 0959-4388

Digital Object Identifier (DOI)

  • 10.1016/s0959-4388(98)80062-7

Language

  • eng