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Race, common genetic variation, and therapeutic response disparities in heart failure.

Publication ,  Journal Article
Taylor, MR; Sun, AY; Davis, G; Fiuzat, M; Liggett, SB; Bristow, MR
Published in: JACC Heart Fail
December 2014

Because of its comparatively recent evolution, Homo sapiens exhibit relatively little within-species genomic diversity. However, because of genome size, a proportionately small amount of variation creates ample opportunities for both rare mutations that may cause disease as well as more common genetic variations that may be important in disease modification or pharmacogenetics. Primarily because of the East African origin of modern humans, individuals of African ancestry (AA) exhibit greater degrees of genetic diversity than more recently established populations, such as those of European ancestry (EA) or Asian ancestry. Those population effects extend to differences in frequency of common gene variants that may be important in heart failure natural history or therapy. For cell-signaling mechanisms important in heart failure, we review and present new data for genetic variation between AA and EA populations. Data indicate that: 1) neurohormonal signaling mechanisms frequently (16 of the 19 investigated polymorphisms) exhibit racial differences in the allele frequencies of variants comprising key constituents; 2) some of these differences in allele frequency may differentially affect the natural history of heart failure in AA compared with EA individuals; and 3) in many cases, these differences likely play a role in observed racial differences in drug or device response.

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Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

December 2014

Volume

2

Issue

6

Start / End Page

561 / 572

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Signal Transduction
  • Receptors, Adrenergic
  • Racial Groups
  • Polymorphism, Single Nucleotide
  • Humans
  • Heart Failure
  • Genotype
  • Genetic Variation
  • Gene Frequency
 

Citation

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Taylor, M. R., Sun, A. Y., Davis, G., Fiuzat, M., Liggett, S. B., & Bristow, M. R. (2014). Race, common genetic variation, and therapeutic response disparities in heart failure. JACC Heart Fail, 2(6), 561–572. https://doi.org/10.1016/j.jchf.2014.06.010
Taylor, Mathew R., Albert Y. Sun, Gordon Davis, Mona Fiuzat, Stephen B. Liggett, and Michael R. Bristow. “Race, common genetic variation, and therapeutic response disparities in heart failure.JACC Heart Fail 2, no. 6 (December 2014): 561–72. https://doi.org/10.1016/j.jchf.2014.06.010.
Taylor MR, Sun AY, Davis G, Fiuzat M, Liggett SB, Bristow MR. Race, common genetic variation, and therapeutic response disparities in heart failure. JACC Heart Fail. 2014 Dec;2(6):561–72.
Taylor, Mathew R., et al. “Race, common genetic variation, and therapeutic response disparities in heart failure.JACC Heart Fail, vol. 2, no. 6, Dec. 2014, pp. 561–72. Pubmed, doi:10.1016/j.jchf.2014.06.010.
Taylor MR, Sun AY, Davis G, Fiuzat M, Liggett SB, Bristow MR. Race, common genetic variation, and therapeutic response disparities in heart failure. JACC Heart Fail. 2014 Dec;2(6):561–572.
Journal cover image

Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

December 2014

Volume

2

Issue

6

Start / End Page

561 / 572

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Signal Transduction
  • Receptors, Adrenergic
  • Racial Groups
  • Polymorphism, Single Nucleotide
  • Humans
  • Heart Failure
  • Genotype
  • Genetic Variation
  • Gene Frequency