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Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study.

Publication ,  Journal Article
Tuchman, SA; Lane, A; Hornsby, WE; Bishop, C; Thomas, S; Herndon, JE; Long, G; Gasparetto, C; Jones, LW
Published in: Clin Lymphoma Myeloma Leuk
February 2015

BACKGROUND: The safety and feasibility of the symptom-limited cardiopulmonary exercise test (CPET) and the 6-minute walk test (6MWT) has not been rigorously tested in patients with multiple myeloma (MM) after high-dose chemotherapy with autologous stem cell transplantation (ASCT), nor have correlations with patient-reported outcomes (PROs) been explored. PATIENTS AND METHODS: We undertook CPET, 6MWT, and PRO assessments using standardized measurements and questionnaires in patients with MM in remission after ASCT. RESULTS: A total of 22 patients who were a median of 17 months after ASCT underwent assessment. No severe adverse events were observed. Exercise capacity, measured during CPET as the peak oxygen consumption, was 17.5 ± 5.9 mL/kg/min, the equivalent of 38% ± 18% less than that for age- and sex-predicted sedentary normative values. During the 6MWT, the mean 6-minute walk distance was 500 m, or 25% ± 13% less than the predicted values. Additional analysis using Pearson's correlation revealed no significant univariate associations between exercise or functional capacity and any PROs. CONCLUSION: Patients with MM have marked and significant reductions in quantitative measures of physical function for years after the initial therapy, although that did not correlate with PROs in the present pilot study. Larger prospective studies are required to determine the clinical ramifications of these findings and to mechanistically dissect them, as well to test interventions aimed at mitigating them.

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Published In

Clin Lymphoma Myeloma Leuk

DOI

EISSN

2152-2669

Publication Date

February 2015

Volume

15

Issue

2

Start / End Page

103 / 109

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Transplantation Conditioning
  • Multiple Myeloma
  • Middle Aged
  • Male
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Female
  • Feasibility Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Tuchman, S. A., Lane, A., Hornsby, W. E., Bishop, C., Thomas, S., Herndon, J. E., … Jones, L. W. (2015). Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study. Clin Lymphoma Myeloma Leuk, 15(2), 103–109. https://doi.org/10.1016/j.clml.2014.09.002
Tuchman, Sascha A., Amy Lane, Whitney E. Hornsby, Caroline Bishop, Samantha Thomas, James E. Herndon, Gwynn Long, Cristina Gasparetto, and Lee W. Jones. “Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study.Clin Lymphoma Myeloma Leuk 15, no. 2 (February 2015): 103–9. https://doi.org/10.1016/j.clml.2014.09.002.
Tuchman SA, Lane A, Hornsby WE, Bishop C, Thomas S, Herndon JE, et al. Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study. Clin Lymphoma Myeloma Leuk. 2015 Feb;15(2):103–9.
Tuchman, Sascha A., et al. “Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study.Clin Lymphoma Myeloma Leuk, vol. 15, no. 2, Feb. 2015, pp. 103–09. Pubmed, doi:10.1016/j.clml.2014.09.002.
Tuchman SA, Lane A, Hornsby WE, Bishop C, Thomas S, Herndon JE, Long G, Gasparetto C, Jones LW. Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study. Clin Lymphoma Myeloma Leuk. 2015 Feb;15(2):103–109.
Journal cover image

Published In

Clin Lymphoma Myeloma Leuk

DOI

EISSN

2152-2669

Publication Date

February 2015

Volume

15

Issue

2

Start / End Page

103 / 109

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Transplantation Conditioning
  • Multiple Myeloma
  • Middle Aged
  • Male
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Female
  • Feasibility Studies