Chronic kidney disease and stroke.

Published

Journal Article (Review)

Chronic kidney disease (CKD) is associated with an increased risk of both ischemic and hemorrhagic stroke. In addition to shared risk factors, this higher cerebrovascular risk is mediated by several CKD-associated mechanisms including platelet dysfunction, coagulation disorders, endothelial dysfunction, inflammation, and increased risk of atrial fibrillation. CKD can also modify the effect of treatments used in acute stroke and in secondary stroke prevention. We review the epidemiology and pathophysiology that link CKD and stroke and the impact of CKD on stroke outcomes. Interdisciplinary collaboration between nephrologists, pharmacists, hematologists, nutrition therapists, primary care physicians, and neurologists in providing care to these subjects may potentially improve outcomes.

Full Text

Duke Authors

Cited Authors

  • El Husseini, N; Kaskar, O; Goldstein, LB

Published Date

  • November 2014

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 500 - 508

PubMed ID

  • 25443575

Pubmed Central ID

  • 25443575

Electronic International Standard Serial Number (EISSN)

  • 1548-5609

International Standard Serial Number (ISSN)

  • 1548-5595

Digital Object Identifier (DOI)

  • 10.1053/j.ackd.2014.09.001

Language

  • eng