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Clinical outcomes in very low birth weight infants with major congenital heart defects.

Publication ,  Journal Article
Anderson, AW; Smith, PB; Corey, KM; Hill, KD; Zimmerman, KO; Clark, RH; Hornik, CP
Published in: Early Hum Dev
December 2014

BACKGROUND: The combination of major congenital heart disease (CHD) and prematurity is associated with poor prognosis, but previous studies have not fully characterized morbidity and mortality in this population. We conducted a retrospective cohort study of very low birth weight (VLBW) infants with major CHD to describe outcomes, including mortality, over time. METHODS: We included all infants <1500 g birth weight with major CHD discharged from Pediatrix Medical Group neonatal intensive care units from 1997 to 2012. We report incidences of major CHD in VLBW infants and compare mortality and morbidity by infant birth weight, type of major CHD, and time period. RESULTS: Of 105,539 VLBW infants, 299 (0.3%) were diagnosed with 15 different major CHDs. Coarctation of the aorta (n=67, 22%), atrioventricular septal defect (n=58, 19%), and tetralogy of Fallot (n=53, 18%) were the most common major CHDs identified. Overall mortality was 163/299 (55%). Mortality was ≥70% for 10 lesions and <30% for isolated aortic valve stenosis (6/30, 20%). Mortality in infants with major CHD did not significantly change over time: 76/133 (57%) in 1997-2005, 49/95 (52%) in 2006-2009, and 38/71 (54%) in 2010-2012 (p=0.70). The majority of infants suffered ≥1 comorbidity or died (218/299, 73%). CONCLUSION: Major CHD is associated with high morbidity and mortality. While mortality varies by lesion, overall survival and incidence of major morbidity have not improved over time.

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Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

December 2014

Volume

90

Issue

12

Start / End Page

791 / 795

Location

Ireland

Related Subject Headings

  • Survival Analysis
  • Retrospective Studies
  • Pediatrics
  • Morbidity
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Newborn
  • Incidence
  • Humans
  • Heart Defects, Congenital
 

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Anderson, A. W., Smith, P. B., Corey, K. M., Hill, K. D., Zimmerman, K. O., Clark, R. H., & Hornik, C. P. (2014). Clinical outcomes in very low birth weight infants with major congenital heart defects. Early Hum Dev, 90(12), 791–795. https://doi.org/10.1016/j.earlhumdev.2014.09.006
Anderson, Anna W., P Brian Smith, Kristin M. Corey, Kevin D. Hill, Kanecia O. Zimmerman, Reese H. Clark, and Christoph P. Hornik. “Clinical outcomes in very low birth weight infants with major congenital heart defects.Early Hum Dev 90, no. 12 (December 2014): 791–95. https://doi.org/10.1016/j.earlhumdev.2014.09.006.
Anderson AW, Smith PB, Corey KM, Hill KD, Zimmerman KO, Clark RH, et al. Clinical outcomes in very low birth weight infants with major congenital heart defects. Early Hum Dev. 2014 Dec;90(12):791–5.
Anderson, Anna W., et al. “Clinical outcomes in very low birth weight infants with major congenital heart defects.Early Hum Dev, vol. 90, no. 12, Dec. 2014, pp. 791–95. Pubmed, doi:10.1016/j.earlhumdev.2014.09.006.
Anderson AW, Smith PB, Corey KM, Hill KD, Zimmerman KO, Clark RH, Hornik CP. Clinical outcomes in very low birth weight infants with major congenital heart defects. Early Hum Dev. 2014 Dec;90(12):791–795.
Journal cover image

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

December 2014

Volume

90

Issue

12

Start / End Page

791 / 795

Location

Ireland

Related Subject Headings

  • Survival Analysis
  • Retrospective Studies
  • Pediatrics
  • Morbidity
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Newborn
  • Incidence
  • Humans
  • Heart Defects, Congenital