An overview of naturally occurring histone deacetylase inhibitors.

Journal Article (Review)

Histone deacetylases (HDACs) have recently emerged as key elements in epigenetic control of gene expression. Due to the implication of HDACs in a variety of diseases ranging from cancer to neurodegenerative disorder, HDAC inhibitors have received increased attention in recent years. Over the last few decades, a myriad of HDAC inhibitors containing a wide variety of structural features have been identified from natural sources. Here, we review the discovery, synthesis, biological properties, and modes of action of these naturally occurring HDAC inhibitors and consider their implications for future research.

Full Text

Duke Authors

Cited Authors

  • Kim, B; Hong, J

Published Date

  • January 2015

Published In

Volume / Issue

  • 14 / 24

Start / End Page

  • 2759 - 2782

PubMed ID

  • 25487010

Electronic International Standard Serial Number (EISSN)

  • 1873-4294

International Standard Serial Number (ISSN)

  • 1568-0266

Digital Object Identifier (DOI)

  • 10.2174/1568026615666141208105614

Language

  • eng