Bacterial meningitis in infants.

Journal Article (Review)

Neonatal bacterial meningitis is uncommon but devastating. Morbidity among survivors remains high. The types and distribution of pathogens are related to gestational age, postnatal age, and geographic region. Confirming the diagnosis is difficult. Clinical signs are often subtle, lumbar punctures are frequently deferred, and cerebrospinal fluid (CSF) cultures can be compromised by prior antibiotic exposure. Infants with bacterial meningitis can have negative blood cultures and normal CSF parameters. Promising tests such as the polymerase chain reaction require further study. Prompt treatment with antibiotics is essential. Clinical trials investigating a vaccine for preventing neonatal Group B Streptococcus infections are ongoing.

Full Text

Duke Authors

Cited Authors

  • Ku, LC; Boggess, KA; Cohen-Wolkowiez, M

Published Date

  • March 2015

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 29 - viii

PubMed ID

  • 25677995

Electronic International Standard Serial Number (EISSN)

  • 1557-9840

International Standard Serial Number (ISSN)

  • 0095-5108

Digital Object Identifier (DOI)

  • 10.1016/j.clp.2014.10.004

Language

  • eng