Ablative therapies for central airway obstruction.

Journal Article (Journal Article;Review)

Central airway obstruction (CAO) is seen in malignant and nonmalignant airway disorders and can lead to significant morbidity and mortality. Endobronchial ablative therapies are used in conjunction with mechanical debridement to achieve hemostasis and restore airway patency. These therapies can be classified into modalities with immediate or delayed effect. Therapies with immediate effect include heat therapies (such as electrocautery, argon plasma coagulation, and laser) and cryorecanalization using a cryoprobe for tissue extraction. These modalities can be used in severe CAO for immediate relief of obstruction. Therapies with delayed effect include cryotherapy, brachytherapy, and photodynamic therapy. These modalities should not be used for acutely symptomatic CAO, and typically require follow-up bronchoscopy for removal of debris from the airway. Multimodality approach typically leads to better outcomes.

Full Text

Duke Authors

Cited Authors

  • Mahmood, K; Wahidi, MM

Published Date

  • December 2014

Published In

Volume / Issue

  • 35 / 6

Start / End Page

  • 681 - 692

PubMed ID

  • 25463159

Electronic International Standard Serial Number (EISSN)

  • 1098-9048

Digital Object Identifier (DOI)

  • 10.1055/s-0034-1395501


  • eng

Conference Location

  • United States