Cell polarity: netrin calms an excitable system.


Journal Article

In a tractable model for cell invasion, the Caenorhabditis elegans anchor cell migrates through basement membranes towards a polarity cue provided by netrin. A new study reveals that the anchor cell polarity network can break symmetry and oscillate in the absence of netrin, suggesting the presence of interlinked positive and negative feedback loops, which are common in polarity pathways.

Full Text

Duke Authors

Cited Authors

  • McClure, AW; Lew, DJ

Published Date

  • November 3, 2014

Published In

Volume / Issue

  • 24 / 21

Start / End Page

  • R1050 - R1052

PubMed ID

  • 25517371

Pubmed Central ID

  • 25517371

Electronic International Standard Serial Number (EISSN)

  • 1879-0445

Digital Object Identifier (DOI)

  • 10.1016/j.cub.2014.09.042


  • eng

Conference Location

  • England