Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease.


Journal Article (Review)

Fibroblast growth factor homologous factors (FHFs) are a noncanonical subset of intracellular fibroblast growth factors that have been implicated in a variety of neurobiological processes and in disease. They are most prominently regulators of voltage-gated Na(+) channels (NaVs). In this review, we discuss new insights into how FHFs modulate NaVs. This is followed by a summary of a growing body of evidence that FHFs operate in much broader fashion. Finally, we highlight unknown aspects of FHF function as areas of future interest.

Full Text

Duke Authors

Cited Authors

  • Pablo, JL; Pitt, GS

Published Date

  • February 2016

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • 19 - 25

PubMed ID

  • 25492945

Pubmed Central ID

  • 25492945

Electronic International Standard Serial Number (EISSN)

  • 1089-4098

Digital Object Identifier (DOI)

  • 10.1177/1073858414562217


  • eng

Conference Location

  • United States