The interplay between CKD, sudden cardiac death, and ventricular arrhythmias.

Journal Article (Journal Article;Review)

CKD patients face an increased risk of cardiovascular disease mortality, and the risk of sudden cardiac death (SCD) increases as kidney function declines. Risk factors for SCD are poorly understood and understudied among CKD patients. In the general population, coronary heart disease-associated risk factors are the most important determinants of SCD risk, but among CKD patients, there is evidence that these factors play a much smaller role. Complex relationships between CKD-specific risk factors, structural heart disease, and arrhythmic triggers contribute to the high risk of SCD and ventricular arrhythmias and modulate the effectiveness of available therapies. This review examines recent data on the epidemiology, pathophysiology, and mechanisms of SCD among CKD patients and examines current evidence regarding the use of pharmacologic and device-based therapies for management of SCD risk.

Full Text

Duke Authors

Cited Authors

  • Pun, PH

Published Date

  • November 2014

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 480 - 488

PubMed ID

  • 25443573

Pubmed Central ID

  • PMC4255332

Electronic International Standard Serial Number (EISSN)

  • 1548-5609

Digital Object Identifier (DOI)

  • 10.1053/j.ackd.2014.06.007


  • eng

Conference Location

  • United States