Association between somatic growth trajectory and cognitive functioning in young children with sickle cell disease.

Journal Article (Journal Article)

Children with sickle cell disease are at risk of cognitive deficits and somatic growth delays beginning in early childhood. We examined growth velocity from age 2 years (height and body mass index progression over time) and cognitive functioning in 46 children with sickle cell disease 4 to 8 years of age. Height-for-age velocity was not associated with cognitive outcomes. Higher body mass index velocity was associated with higher scores on global cognitive and visual-motor abilities but not processing resources or academic achievement. Body mass index progression over time may be a clinically useful indicator of neurocognitive risk in sickle cell disease, as it may reflect multiple sickle cell disease-related risk factors.

Full Text

Duke Authors

Cited Authors

  • Puffer, ES; Schatz, JC; Roberts, CW

Published Date

  • August 2016

Published In

Volume / Issue

  • 21 / 8

Start / End Page

  • 1620 - 1629

PubMed ID

  • 25488939

Electronic International Standard Serial Number (EISSN)

  • 1461-7277

International Standard Serial Number (ISSN)

  • 1359-1053

Digital Object Identifier (DOI)

  • 10.1177/1359105314559861


  • eng