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Transcription-associated mutagenesis.

Publication ,  Journal Article
Jinks-Robertson, S; Bhagwat, AS
Published in: Annu Rev Genet
2014

Transcription requires unwinding complementary DNA strands, generating torsional stress, and sensitizing the exposed single strands to chemical reactions and endogenous damaging agents. In addition, transcription can occur concomitantly with the other major DNA metabolic processes (replication, repair, and recombination), creating opportunities for either cooperation or conflict. Genetic modifications associated with transcription are a global issue in the small genomes of microorganisms in which noncoding sequences are rare. Transcription likewise becomes significant when one considers that most of the human genome is transcriptionally active. In this review, we focus specifically on the mutagenic consequences of transcription. Mechanisms of transcription-associated mutagenesis in microorganisms are discussed, as is the role of transcription in somatic instability of the vertebrate immune system.

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Published In

Annu Rev Genet

DOI

EISSN

1545-2948

Publication Date

2014

Volume

48

Start / End Page

341 / 359

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Saccharomycetales
  • Mutagenesis
  • Humans
  • Developmental Biology
  • DNA, Single-Stranded
  • DNA Replication
  • DNA Damage
  • Bacteria
  • 3105 Genetics
 

Citation

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ICMJE
MLA
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Jinks-Robertson, S., & Bhagwat, A. S. (2014). Transcription-associated mutagenesis. Annu Rev Genet, 48, 341–359. https://doi.org/10.1146/annurev-genet-120213-092015
Jinks-Robertson, Sue, and Ashok S. Bhagwat. “Transcription-associated mutagenesis.Annu Rev Genet 48 (2014): 341–59. https://doi.org/10.1146/annurev-genet-120213-092015.
Jinks-Robertson S, Bhagwat AS. Transcription-associated mutagenesis. Annu Rev Genet. 2014;48:341–59.
Jinks-Robertson, Sue, and Ashok S. Bhagwat. “Transcription-associated mutagenesis.Annu Rev Genet, vol. 48, 2014, pp. 341–59. Pubmed, doi:10.1146/annurev-genet-120213-092015.
Jinks-Robertson S, Bhagwat AS. Transcription-associated mutagenesis. Annu Rev Genet. 2014;48:341–359.

Published In

Annu Rev Genet

DOI

EISSN

1545-2948

Publication Date

2014

Volume

48

Start / End Page

341 / 359

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Saccharomycetales
  • Mutagenesis
  • Humans
  • Developmental Biology
  • DNA, Single-Stranded
  • DNA Replication
  • DNA Damage
  • Bacteria
  • 3105 Genetics