Transcription-associated mutagenesis.

Published

Journal Article (Review)

Transcription requires unwinding complementary DNA strands, generating torsional stress, and sensitizing the exposed single strands to chemical reactions and endogenous damaging agents. In addition, transcription can occur concomitantly with the other major DNA metabolic processes (replication, repair, and recombination), creating opportunities for either cooperation or conflict. Genetic modifications associated with transcription are a global issue in the small genomes of microorganisms in which noncoding sequences are rare. Transcription likewise becomes significant when one considers that most of the human genome is transcriptionally active. In this review, we focus specifically on the mutagenic consequences of transcription. Mechanisms of transcription-associated mutagenesis in microorganisms are discussed, as is the role of transcription in somatic instability of the vertebrate immune system.

Full Text

Duke Authors

Cited Authors

  • Jinks-Robertson, S; Bhagwat, AS

Published Date

  • 2014

Published In

Volume / Issue

  • 48 /

Start / End Page

  • 341 - 359

PubMed ID

  • 25251854

Pubmed Central ID

  • 25251854

Electronic International Standard Serial Number (EISSN)

  • 1545-2948

Digital Object Identifier (DOI)

  • 10.1146/annurev-genet-120213-092015

Language

  • eng

Conference Location

  • United States