Role of T lymphocytes in hypertension.

Journal Article (Journal Article;Review)

Accumulating evidence indicates that the immune system plays a critical role in the pathogenesis of cardiovascular diseases including hypertension. Mice lacking T lymphocytes are resistant to blood pressure elevation, suggesting a key contribution of T lymphocytes to hypertension. However, the individual T cell subsets, including CD8(+), Th1, Th17, and T regulatory T cells have shown widely discrepant effects on blood pressure and target organ damage in this disorder. Moreover, the activation state of a T lymphocyte population exerts considerable influence over its role in hypertension. In turn, activated T cells regulate blood pressure through the elaboration of reactive oxygen species and vasoactive cytokines, altering the inflammatory milieu in the vascular wall and the kidney. Recent GWAS studies similarly point to a role for T lymphocytes in human hypertension.

Full Text

Duke Authors

Cited Authors

  • Zhang, J; Crowley, SD

Published Date

  • April 2015

Published In

Volume / Issue

  • 21 /

Start / End Page

  • 14 - 19

PubMed ID

  • 25523165

Pubmed Central ID

  • PMC4380788

Electronic International Standard Serial Number (EISSN)

  • 1471-4973

Digital Object Identifier (DOI)

  • 10.1016/j.coph.2014.12.003


  • eng

Conference Location

  • England