A method for estimating and removing streaking artifacts in quantitative susceptibility mapping.


Journal Article

Quantitative susceptibility mapping (QSM) is a novel MRI method for quantifying tissue magnetic property. In the brain, it reflects the molecular composition and microstructure of the local tissue. However, susceptibility maps reconstructed from single-orientation data still suffer from streaking artifacts which obscure structural details and small lesions. We propose and have developed a general method for estimating streaking artifacts and subtracting them from susceptibility maps. Specifically, this method uses a sparse linear equation and least-squares (LSQR)-algorithm-based method to derive an initial estimation of magnetic susceptibility, a fast quantitative susceptibility mapping method to estimate the susceptibility boundaries, and an iterative approach to estimate the susceptibility artifact from ill-conditioned k-space regions only. With a fixed set of parameters for the initial susceptibility estimation and subsequent streaking artifact estimation and removal, the method provides an unbiased estimate of tissue susceptibility with negligible streaking artifacts, as compared to multi-orientation QSM reconstruction. This method allows for improved delineation of white matter lesions in patients with multiple sclerosis and small structures of the human brain with excellent anatomical details. The proposed methodology can be extended to other existing QSM algorithms.

Full Text

Duke Authors

Cited Authors

  • Li, W; Wang, N; Yu, F; Han, H; Cao, W; Romero, R; Tantiwongkosi, B; Duong, TQ; Liu, C

Published Date

  • March 2015

Published In

Volume / Issue

  • 108 /

Start / End Page

  • 111 - 122

PubMed ID

  • 25536496

Pubmed Central ID

  • 25536496

Electronic International Standard Serial Number (EISSN)

  • 1095-9572

Digital Object Identifier (DOI)

  • 10.1016/j.neuroimage.2014.12.043


  • eng

Conference Location

  • United States