Metabolic regulation and energy homeostasis through the primary Cilium.

Journal Article (Review)

Obesity and diabetes represent a significant healthcare concern. In contrast to genome-wide association studies that, some exceptions notwithstanding, have offered modest clues about pathomechanism, the dissection of rare disorders in which obesity represents a core feature have highlighted key molecules and structures critical to energy regulation. Here we focus on the primary cilium, an organelle whose roles in energy homeostasis have been underscored by the high incidence of obesity and type II diabetes in patients and mouse mutants with compromised ciliary function. We discuss recent evidence linking ciliary dysfunction to metabolic defects and we explore the contribution of neuronal and nonneuronal cilia to these phenotypes.

Full Text

Duke Authors

Cited Authors

  • Oh, EC; Vasanth, S; Katsanis, N

Published Date

  • January 2015

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 21 - 31

PubMed ID

  • 25543293

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

International Standard Serial Number (ISSN)

  • 1550-4131

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2014.11.019

Language

  • eng