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Radiation-induced malignant gliomas: a current review.

Publication ,  Journal Article
Elsamadicy, AA; Babu, R; Kirkpatrick, JP; Adamson, DC
Published in: World Neurosurg
April 2015

OBJECTIVE: Radiation-induced malignant gliomas (RIMGs) are known uncommon risks of brain irradiation. We describe 4 cases of RIMG that occurred at our institution and conduct the largest comprehensive review of the literature to characterize RIMGs better. METHODS: Patients were identified through the PubMed database. Pearson R linear correlation test was used to evaluate the correlation between radiotherapy (RT) dose and age and latency period. Student t test was used to evaluate differences between latency periods for original tumor lesions. A normalized biologic equivalent dose analysis was performed to indicate the minimum and maximum radiation threshold for neoplasia. A Kaplan-Meier analysis was used to illustrate the overall survival curves. RESULTS: The analysis included 172 cases from the PubMed database and 4 cases occurring at our institution. The median RT dose administered was 35.6 Gy, with the most common dosage ranges being 21-30 Gy (31%) and 41-50 Gy (21.5%). Median latency period was 9 years until diagnosis of RIMG, and RIMG occurred within 15 years in 82% of the patients. There was no correlation between the age of the patient at the time RT was administered (R(2) = 0.00081) or amount of RT (R(2) = 0.00005) and latency period for RIMG. The mean biologic equivalent dose for neoplasia of a RIMG was 63.3 Gy. The median survival of patients with RIMG improved over time (P = 0.004), with median survival of 9 months before 2007 and 11.5 months after 2007. CONCLUSIONS: The risk of RIMG appears to be the same for all age groups, histologies, and RT dosages. Although the risk is low, patients should be aware of RIMG as a possible complication of brain irradiation.

Duke Scholars

Published In

World Neurosurg

DOI

EISSN

1878-8769

Publication Date

April 2015

Volume

83

Issue

4

Start / End Page

530 / 542

Location

United States

Related Subject Headings

  • Survival Analysis
  • Radiotherapy
  • Neoplasms, Radiation-Induced
  • Humans
  • Glioma
  • Brain Neoplasms
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Elsamadicy, A. A., Babu, R., Kirkpatrick, J. P., & Adamson, D. C. (2015). Radiation-induced malignant gliomas: a current review. World Neurosurg, 83(4), 530–542. https://doi.org/10.1016/j.wneu.2014.12.009
Elsamadicy, Aladine A., Ranjith Babu, John P. Kirkpatrick, and David Cory Adamson. “Radiation-induced malignant gliomas: a current review.World Neurosurg 83, no. 4 (April 2015): 530–42. https://doi.org/10.1016/j.wneu.2014.12.009.
Elsamadicy AA, Babu R, Kirkpatrick JP, Adamson DC. Radiation-induced malignant gliomas: a current review. World Neurosurg. 2015 Apr;83(4):530–42.
Elsamadicy, Aladine A., et al. “Radiation-induced malignant gliomas: a current review.World Neurosurg, vol. 83, no. 4, Apr. 2015, pp. 530–42. Pubmed, doi:10.1016/j.wneu.2014.12.009.
Elsamadicy AA, Babu R, Kirkpatrick JP, Adamson DC. Radiation-induced malignant gliomas: a current review. World Neurosurg. 2015 Apr;83(4):530–542.
Journal cover image

Published In

World Neurosurg

DOI

EISSN

1878-8769

Publication Date

April 2015

Volume

83

Issue

4

Start / End Page

530 / 542

Location

United States

Related Subject Headings

  • Survival Analysis
  • Radiotherapy
  • Neoplasms, Radiation-Induced
  • Humans
  • Glioma
  • Brain Neoplasms
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences