Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

Variations in cord blood manufacturing and administration are common, and the optimal practice is not known. We compared processing and banking practices at 16 public cord blood banks (CBB) in the United States and assessed transplantation outcomes on 530 single umbilical cord blood (UCB) myeloablative transplantations for hematologic malignancies facilitated by these banks. UCB banking practices were separated into 3 mutually exclusive groups based on whether processing was automated or manual, units were plasma and red blood cell reduced, or buffy coat production method or plasma reduced. Compared with the automated processing system for units, the day 28 neutrophil recovery was significantly lower after transplantation of units that were manually processed and plasma reduced (red cell replete) (odds ratio, .19; P = .001) or plasma and red cell reduced (odds ratio, .54; P = .05). Day 100 survival did not differ by CBB. However, day 100 survival was better with units that were thawed with the dextran-albumin wash method compared with the "no wash" or "dilution only" techniques (odds ratio, 1.82; P = .04). In conclusion, CBB processing has no significant effect on early (day 100) survival despite differences in kinetics of neutrophil recovery.

Full Text

Duke Authors

Cited Authors

  • Ballen, KK; Logan, BR; Laughlin, MJ; He, W; Ambruso, DR; Armitage, SE; Beddard, RL; Bhatla, D; Hwang, WYK; Kiss, JE; Koegler, G; Kurtzberg, J; Nagler, A; Oh, D; Petz, LD; Price, TH; Quinones, RR; Ratanatharathorn, V; Rizzo, JD; Sazama, K; Scaradavou, A; Schuster, MW; Sender, LS; Shpall, EJ; Spellman, SR; Sutton, M; Weitekamp, LA; Wingard, JR; Eapen, M

Published Date

  • April 2015

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 688 - 695

PubMed ID

  • 25543094

Pubmed Central ID

  • PMC4359657

Electronic International Standard Serial Number (EISSN)

  • 1523-6536

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2014.12.017


  • eng

Conference Location

  • United States