Real-time, computer-assisted quantification of plus disease in retinopathy of prematurity at the bedside.

Journal Article (Journal Article)

BACKGROUND AND OBJECTIVE: Plus disease is the primary indication for retinopathy of prematurity (ROP) treatment, but in borderline cases ophthalmologists may struggle to judge whether it is present. ROPtool is a semi-automated computer program that objectively assesses plus disease by measuring retinal vascular tortuosity and width. This study determined ROPtool's bedside diagnostic accuracy concurrent with ROP screening. PATIENTS AND METHODS: ROP screening examinations were recorded using Keeler video indirect ophthalmoscopy. A masked operator traced images in ROPtool at the bedside, comparing ROPtool's plus diagnosis to the examiner's clinical judgment. RESULTS: Four hundred sixty-four examinations (129 eyes of 65 infants) were performed. ROPtool's sensitivity, specificity, and area under the receiver operating characteristic curve for plus diagnosis was 71% (CI: 38%-100%), 93% (CI: 89%-98%) and 0.87, and for pre-plus or worse was 68% (CI: 51%-85%), 82% (CI: 77%-86%) and 0.81, respectively. CONCLUSION: ROPtool can provide a real-time second opinion of plus disease at the bedside. Image enhancement technologies may further improve ROPtool's diagnostic accuracy.

Full Text

Duke Authors

Cited Authors

  • Cabrera, MT; Freedman, SF; Hartnett, ME; Stinnett, SS; Chen, BB; Wallace, DK

Published Date

  • 2014

Published In

Volume / Issue

  • 45 / 6

Start / End Page

  • 542 - 548

PubMed ID

  • 25423634

Pubmed Central ID

  • PMC4703591

Electronic International Standard Serial Number (EISSN)

  • 2325-8179

Digital Object Identifier (DOI)

  • 10.3928/23258160-20141118-09


  • eng

Conference Location

  • United States