Real-time, computer-assisted quantification of plus disease in retinopathy of prematurity at the bedside.

Journal Article

Plus disease is the primary indication for retinopathy of prematurity (ROP) treatment, but in borderline cases ophthalmologists may struggle to judge whether it is present. ROPtool is a semi-automated computer program that objectively assesses plus disease by measuring retinal vascular tortuosity and width. This study determined ROPtool's bedside diagnostic accuracy concurrent with ROP screening.ROP screening examinations were recorded using Keeler video indirect ophthalmoscopy. A masked operator traced images in ROPtool at the bedside, comparing ROPtool's plus diagnosis to the examiner's clinical judgment.Four hundred sixty-four examinations (129 eyes of 65 infants) were performed. ROPtool's sensitivity, specificity, and area under the receiver operating characteristic curve for plus diagnosis was 71% (CI: 38%-100%), 93% (CI: 89%-98%) and 0.87, and for pre-plus or worse was 68% (CI: 51%-85%), 82% (CI: 77%-86%) and 0.81, respectively.ROPtool can provide a real-time second opinion of plus disease at the bedside. Image enhancement technologies may further improve ROPtool's diagnostic accuracy.

Full Text

Duke Authors

Cited Authors

  • Cabrera, MT; Freedman, SF; Hartnett, ME; Stinnett, SS; Chen, BB; Wallace, DK

Published Date

  • November 2014

Published In

Volume / Issue

  • 45 / 6

Start / End Page

  • 542 - 548

PubMed ID

  • 25423634

Electronic International Standard Serial Number (EISSN)

  • 2325-8179

International Standard Serial Number (ISSN)

  • 2325-8160

Digital Object Identifier (DOI)

  • 10.3928/23258160-20141118-09


  • eng