Predicting recurrent mitral regurgitation after mitral valve repair for severe ischemic mitral regurgitation.

Journal Article (Journal Article;Multicenter Study)

OBJECTIVES: The Cardiothoracic Surgical Trials Network recently reported no difference in the primary end point of left ventricular end-systolic volume index at 1 year postsurgery in patients randomized to repair (n = 126) or replacement (n = 125) for severe ischemic mitral regurgitation. However, patients undergoing repair experienced significantly more recurrent mitral regurgitation than patients undergoing replacement (32.6% vs 2.3%). We examined whether baseline echocardiographic and clinical characteristics could identify those who will develop moderate/severe recurrent mitral regurgitation or die. METHODS: Our analysis includes 116 patients who were randomized to and received mitral valve repair. Logistic regression was used to estimate a model-based probability of recurrence or death from baseline factors. Receiver operating characteristic curves were constructed from these estimated probabilities to determine classification cut-points maximizing accuracy of prediction based on sensitivity and specificity. RESULTS: Of the 116 patients, 6 received a replacement before leaving the operating room; all other patients had mild or less mitral regurgitation on intraoperative echocardiogram after repair. During the 2-year follow-up period, 76 patients developed moderate/severe mitral regurgitation or died (53 mitral regurgitation recurrences, 13 mitral regurgitation recurrences and death, and 10 deaths). The mechanism for recurrent mitral regurgitation was largely mitral valve leaflet tethering. Our model (including age, body mass index, sex, race, effective regurgitant orifice area, basal aneurysm/dyskinesis, New York Heart Association class, history of coronary artery bypass grafting, percutaneous coronary intervention, or ventricular arrhythmias) yielded an area under the receiver operating characteristic curve of 0.82. CONCLUSIONS: The model demonstrated good discrimination in identifying patients who will survive 2 years without recurrent mitral regurgitation after mitral valve repair. Although our results require validation, they offer a clinically relevant risk score for selection of surgical candidates for this procedure.

Full Text

Duke Authors

Cited Authors

  • Kron, IL; Hung, J; Overbey, JR; Bouchard, D; Gelijns, AC; Moskowitz, AJ; Voisine, P; O'Gara, PT; Argenziano, M; Michler, RE; Gillinov, M; Puskas, JD; Gammie, JS; Mack, MJ; Smith, PK; Sai-Sudhakar, C; Gardner, TJ; Ailawadi, G; Zeng, X; O'Sullivan, K; Parides, MK; Swayze, R; Thourani, V; Rose, EA; Perrault, LP; Acker, MA; CTSN Investigators,

Published Date

  • March 2015

Published In

Volume / Issue

  • 149 / 3

Start / End Page

  • 752 - 61.e1

PubMed ID

  • 25500293

Pubmed Central ID

  • PMC4687890

Electronic International Standard Serial Number (EISSN)

  • 1097-685X

Digital Object Identifier (DOI)

  • 10.1016/j.jtcvs.2014.10.120


  • eng

Conference Location

  • United States