Caging metal ions with visible light-responsive nanopolymersomes.

Journal Article (Journal Article)

Polymersomes are bilayer vesicles that self-assemble from amphiphilic diblock copolymers, and provide an attractive system for the delivery of biological and nonbiological molecules due to their environmental compatibility, mechanical stability, synthetic tunability, large aqueous core, and hyperthick hydrophobic membrane. Herein, we report a nanoscale photoresponsive polymersome system featuring a meso-to-meso ethyne-bridged bis[(porphinato)zinc] (PZn2) fluorophore hydrophobic membrane solute and dextran in the aqueous core. Upon 488 nm irradiation in solution or in microinjected zebrafish embryos, the polymersomes underwent deformation, as monitored by a characteristic red-shifted PZn2 emission spectrum and confirmed by cryo-TEM. The versatility of this system was demonstrated through the encapsulation and photorelease of a fluorophore (FITC), as well as two different metal ions, Zn(2+) and Ca(2+).

Full Text

Duke Authors

Cited Authors

  • Griepenburg, JC; Sood, N; Vargo, KB; Williams, D; Rawson, J; Therien, MJ; Hammer, DA; Dmochowski, IJ

Published Date

  • January 2015

Published In

Volume / Issue

  • 31 / 2

Start / End Page

  • 799 - 807

PubMed ID

  • 25518002

Pubmed Central ID

  • PMC4303334

Electronic International Standard Serial Number (EISSN)

  • 1520-5827

International Standard Serial Number (ISSN)

  • 0743-7463

Digital Object Identifier (DOI)

  • 10.1021/la5036689


  • eng