How I use fibrinogen replacement therapy in acquired bleeding.


Other Article

Fibrinogen is a critical protein for hemostasis and clot formation. However, transfusion guidelines have variable recommendations for maintaining fibrinogen levels in bleeding patients. An increasing number of studies support the practice of fibrinogen replacement therapy for acquired coagulopathies, and additional studies are underway. Fibrinogen therapy can be administered with cryoprecipitate or fibrinogen concentrates, and clinical practice varies according to their availability and licensing status. Fibrinogen concentrate therapy has been studied in animal models and clinical trials and supports the critical role of fibrinogen repletion in bleeding patients. Point-of-care testing will have an important role in guiding fibrinogen replacement for hemostatic therapy in clinical settings such as cardiovascular surgery, postpartum hemorrhage, and trauma. Fibrinogen therapy is an important component of a multimodal strategy for the treatment of coagulopathic bleeding.

Full Text

Duke Authors

Cited Authors

  • Levy, JH; Goodnough, LT

Published Date

  • February 26, 2015

Published In

Volume / Issue

  • 125 / 9

Start / End Page

  • 1387 - 1393

PubMed ID

  • 25519751

Pubmed Central ID

  • 25519751

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

Digital Object Identifier (DOI)

  • 10.1182/blood-2014-08-552000


  • eng

Conference Location

  • United States