Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease.
Publication
, Journal Article
Sun, B; Banugaria, SG; Prater, SN; Patel, TT; Fredrickson, K; Ringler, DJ; de Fougerolles, A; Rosenberg, AS; Waldmann, H; Kishnani, PS
Published in: Mol Genet Metab Rep
2014
Approximately 35-40% of patients with classic infantile Pompe disease treated with enzyme replacement therapy (ERT) develop high, sustained antibody titers against the therapeutic enzyme alglucosidase alfa, which abrogates the treatment efficacy. Induction of antigen-specific immune tolerance would greatly enhance ERT for these patients. Here we show that a short-course treatment with non-depleting anti-CD4 monoclonal antibody successfully induced long-term ERT-specific immune tolerance in Pompe disease mice. Our data suggest an effective adjuvant therapy to ERT.
Duke Scholars
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Published In
Mol Genet Metab Rep
DOI
ISSN
2214-4269
Publication Date
2014
Volume
1
Start / End Page
446 / 450
Location
United States
Related Subject Headings
- 3202 Clinical sciences
- 3105 Genetics
- 0604 Genetics
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Sun, B., Banugaria, S. G., Prater, S. N., Patel, T. T., Fredrickson, K., Ringler, D. J., … Kishnani, P. S. (2014). Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease. Mol Genet Metab Rep, 1, 446–450. https://doi.org/10.1016/j.ymgmr.2014.08.005
Sun, Baodong, Suhrad G. Banugaria, Sean N. Prater, Trusha T. Patel, Keri Fredrickson, Douglas J. Ringler, Antonin de Fougerolles, Amy S. Rosenberg, Herman Waldmann, and Priya S. Kishnani. “Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease.” Mol Genet Metab Rep 1 (2014): 446–50. https://doi.org/10.1016/j.ymgmr.2014.08.005.
Sun B, Banugaria SG, Prater SN, Patel TT, Fredrickson K, Ringler DJ, et al. Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease. Mol Genet Metab Rep. 2014;1:446–50.
Sun, Baodong, et al. “Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease.” Mol Genet Metab Rep, vol. 1, 2014, pp. 446–50. Pubmed, doi:10.1016/j.ymgmr.2014.08.005.
Sun B, Banugaria SG, Prater SN, Patel TT, Fredrickson K, Ringler DJ, de Fougerolles A, Rosenberg AS, Waldmann H, Kishnani PS. Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease. Mol Genet Metab Rep. 2014;1:446–450.
Published In
Mol Genet Metab Rep
DOI
ISSN
2214-4269
Publication Date
2014
Volume
1
Start / End Page
446 / 450
Location
United States
Related Subject Headings
- 3202 Clinical sciences
- 3105 Genetics
- 0604 Genetics
- 0601 Biochemistry and Cell Biology