Surgical treatment of moderate ischemic mitral regurgitation.

Journal Article

BACKGROUND: Ischemic mitral regurgitation is associated with increased mortality and morbidity. For surgical patients with moderate regurgitation, the benefits of adding mitral-valve repair to coronary-artery bypass grafting (CABG) are uncertain. METHODS: We randomly assigned 301 patients with moderate ischemic mitral regurgitation to CABG alone or CABG plus mitral-valve repair (combined procedure). The primary end point was the left ventricular end-systolic volume index (LVESVI), a measure of left ventricular remodeling, at 1 year. This end point was assessed with the use of a Wilcoxon rank-sum test in which deaths were categorized as the lowest LVESVI rank. RESULTS: At 1 year, the mean LVESVI among surviving patients was 46.1±22.4 ml per square meter of body-surface area in the CABG-alone group and 49.6±31.5 ml per square meter in the combined-procedure group (mean change from baseline, -9.4 and -9.3 ml per square meter, respectively). The rate of death was 6.7% in the combined-procedure group and 7.3% in the CABG-alone group (hazard ratio with mitral-valve repair, 0.90; 95% confidence interval, 0.38 to 2.12; P=0.81). The rank-based assessment of LVESVI at 1 year (incorporating deaths) showed no significant between-group difference (z score, 0.50; P=0.61). The addition of mitral-valve repair was associated with a longer bypass time (P<0.001), a longer hospital stay after surgery (P=0.002), and more neurologic events (P=0.03). Moderate or severe mitral regurgitation was less common in the combined-procedure group than in the CABG-alone group (11.2% vs. 31.0%, P<0.001). There were no significant between-group differences in major adverse cardiac or cerebrovascular events, deaths, readmissions, functional status, or quality of life at 1 year. CONCLUSIONS: In patients with moderate ischemic mitral regurgitation, the addition of mitral-valve repair to CABG did not result in a higher degree of left ventricular reverse remodeling. Mitral-valve repair was associated with a reduced prevalence of moderate or severe mitral regurgitation but an increased number of untoward events. Thus, at 1 year, this trial did not show a clinically meaningful advantage of adding mitral-valve repair to CABG. Longer-term follow-up may determine whether the lower prevalence of mitral regurgitation translates into a net clinical benefit. (Funded by the National Institutes of Health and the Canadian Institutes of Health Research; number, NCT00806988.).

Full Text

Duke Authors

Cited Authors

  • Smith, PK; Puskas, JD; Ascheim, DD; Voisine, P; Gelijns, AC; Moskowitz, AJ; Hung, JW; Parides, MK; Ailawadi, G; Perrault, LP; Acker, MA; Argenziano, M; Thourani, V; Gammie, JS; Miller, MA; Pagé, P; Overbey, JR; Bagiella, E; Dagenais, F; Blackstone, EH; Kron, IL; Goldstein, DJ; Rose, EA; Moquete, EG; Jeffries, N; Gardner, TJ; O'Gara, PT; Alexander, JH; Michler, RE; Cardiothoracic Surgical Trials Network Investigators,

Published Date

  • December 4, 2014

Published In

Volume / Issue

  • 371 / 23

Start / End Page

  • 2178 - 2188

PubMed ID

  • 25405390

Pubmed Central ID

  • 25405390

Electronic International Standard Serial Number (EISSN)

  • 1533-4406

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1410490


  • eng

Conference Location

  • United States