Skip to main content

Biomarkers for kidney transplant rejection.

Publication ,  Journal Article
Lo, DJ; Kaplan, B; Kirk, AD
Published in: Nat Rev Nephrol
April 2014

The immune management of organ transplant recipients is imperfect. Beyond general dosing guidelines for immunosuppressive agents and clinical diagnostic tests for rejection or infection, there are few objective tools to determine the aggregate status of a patient's alloimmune response or protective immune capacity. The lack of prognostic precision significantly contributes to patient morbidity and reduces long-term allograft survival after kidney transplantation. Noninvasive biomarkers that could serve as predictive tools or surrogate end points for rejection might help clinicians individualize immunosuppression and allow for early intervention, ideally prior to clinically evident organ dysfunction. Although the growing understanding of organ rejection has provided numerous candidate biomarkers, none has been confirmed in robust validation studies as sufficiently useful to guide clinical practice independent of traditional clinical methods. In this Review, the general characteristics of biomarkers and surrogate end points; current biomarkers under active clinical investigation; and the prominent barriers to the translation of biomarkers into clinical practice are discussed.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Rev Nephrol

DOI

EISSN

1759-507X

Publication Date

April 2014

Volume

10

Issue

4

Start / End Page

215 / 225

Location

England

Related Subject Headings

  • Urology & Nephrology
  • RNA, Messenger
  • Prognosis
  • Pore Forming Cytotoxic Proteins
  • Perforin
  • OX40 Ligand
  • MicroRNAs
  • Membrane Proteins
  • Kidney Transplantation
  • Immunosuppression Therapy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lo, D. J., Kaplan, B., & Kirk, A. D. (2014). Biomarkers for kidney transplant rejection. Nat Rev Nephrol, 10(4), 215–225. https://doi.org/10.1038/nrneph.2013.281
Lo, Denise J., Bruce Kaplan, and Allan D. Kirk. “Biomarkers for kidney transplant rejection.Nat Rev Nephrol 10, no. 4 (April 2014): 215–25. https://doi.org/10.1038/nrneph.2013.281.
Lo DJ, Kaplan B, Kirk AD. Biomarkers for kidney transplant rejection. Nat Rev Nephrol. 2014 Apr;10(4):215–25.
Lo, Denise J., et al. “Biomarkers for kidney transplant rejection.Nat Rev Nephrol, vol. 10, no. 4, Apr. 2014, pp. 215–25. Pubmed, doi:10.1038/nrneph.2013.281.
Lo DJ, Kaplan B, Kirk AD. Biomarkers for kidney transplant rejection. Nat Rev Nephrol. 2014 Apr;10(4):215–225.

Published In

Nat Rev Nephrol

DOI

EISSN

1759-507X

Publication Date

April 2014

Volume

10

Issue

4

Start / End Page

215 / 225

Location

England

Related Subject Headings

  • Urology & Nephrology
  • RNA, Messenger
  • Prognosis
  • Pore Forming Cytotoxic Proteins
  • Perforin
  • OX40 Ligand
  • MicroRNAs
  • Membrane Proteins
  • Kidney Transplantation
  • Immunosuppression Therapy