Primate models in organ transplantation.

Published online

Journal Article (Review)

Large animal models have long served as the proving grounds for advances in transplantation, bridging the gap between inbred mouse experimentation and human clinical trials. Although a variety of species have been and continue to be used, the emergence of highly targeted biologic- and antibody-based therapies has required models to have a high degree of homology with humans. Thus, the nonhuman primate has become the model of choice in many settings. This article will provide an overview of nonhuman primate models of transplantation. Issues of primate genetics and care will be introduced, and a brief overview of technical aspects for various transplant models will be discussed. Finally, several prominent immunosuppressive and tolerance strategies used in primates will be reviewed.

Full Text

Cited Authors

  • Anderson, DJ; Kirk, AD

Published Date

  • September 1, 2013

Published In

Volume / Issue

  • 3 / 9

Start / End Page

  • a015503 -

PubMed ID

  • 24003248

Pubmed Central ID

  • 24003248

Electronic International Standard Serial Number (EISSN)

  • 2157-1422

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a015503

Language

  • eng

Conference Location

  • United States