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Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation.

Publication ,  Journal Article
Mohammed, A; Ulukpo, O; Lawrence, EC; Fernandez, F; Pickens, A; Gal, AA; Force, SD; Easley, KC; Larsen, CP; Kirk, AD; Neujahr, DC
Published in: Transplant Proc
December 2011

Outcomes following lung transplant remain suboptimal. This is attributable to variable posttransplant recovery of lung function, and inconsistent degrees of lung function loss after peak function is reached. Granzyme B is elevated in the blood and bronchoalveolar lavage (BAL) in acute rejection. We hypothesized that persistent exposure to T cells high in granzyme B would negatively correlate with lung function. We investigated cumulative exposure measured as the area-under-the-curve (AUC) of CD8+ T cell granzyme Bhi cells in the first year posttransplant in both BAL and blood in 24 transplant recipients. We assessed the correlation between cumulative 1-year exposure and FEV1 slope. There was a negative correlation between 1-year exposure and FEV1 slope within the first year (r=-0.63; P=.001). This relationship persisted even when adjusted for transplant type, gender, age, rejection, and indication for transplantation. In contrast, no relationship was seen with the 1-year AUC and lung function after 1 year posttransplant. In contrast to the BAL granzyme Bhi levels, granzyme Bhi levels from the blood showed no relationship with lung function. These findings suggest that CD8+ T-cell-driven factors are responsible for early improvements in lung function after transplantation.

Duke Scholars

Published In

Transplant Proc

DOI

EISSN

1873-2623

Publication Date

December 2011

Volume

43

Issue

10

Start / End Page

3892 / 3898

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Spirometry
  • Middle Aged
  • Male
  • Lung Transplantation
  • Lung
  • Least-Squares Analysis
  • Humans
  • Granzymes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mohammed, A., Ulukpo, O., Lawrence, E. C., Fernandez, F., Pickens, A., Gal, A. A., … Neujahr, D. C. (2011). Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation. Transplant Proc, 43(10), 3892–3898. https://doi.org/10.1016/j.transproceed.2011.09.072
Mohammed, A., O. Ulukpo, E. C. Lawrence, F. Fernandez, A. Pickens, A. A. Gal, S. D. Force, et al. “Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation.Transplant Proc 43, no. 10 (December 2011): 3892–98. https://doi.org/10.1016/j.transproceed.2011.09.072.
Mohammed A, Ulukpo O, Lawrence EC, Fernandez F, Pickens A, Gal AA, et al. Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation. Transplant Proc. 2011 Dec;43(10):3892–8.
Mohammed, A., et al. “Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation.Transplant Proc, vol. 43, no. 10, Dec. 2011, pp. 3892–98. Pubmed, doi:10.1016/j.transproceed.2011.09.072.
Mohammed A, Ulukpo O, Lawrence EC, Fernandez F, Pickens A, Gal AA, Force SD, Easley KC, Larsen CP, Kirk AD, Neujahr DC. Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation. Transplant Proc. 2011 Dec;43(10):3892–3898.
Journal cover image

Published In

Transplant Proc

DOI

EISSN

1873-2623

Publication Date

December 2011

Volume

43

Issue

10

Start / End Page

3892 / 3898

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Spirometry
  • Middle Aged
  • Male
  • Lung Transplantation
  • Lung
  • Least-Squares Analysis
  • Humans
  • Granzymes