Protocol biopsies in renal transplantation: insights into patient management and pathogenesis.


Journal Article

A 1-day symposium on the application of protocol biopsies in renal transplantation was held in Boston, 21 July 2006. Representatives from centers with extensive experience in the use of protocol biopsies for routine patient care and research reported results on the pathological findings and their value in patient management. The consensus was that protocol biopsies, in experienced hands, are a safe and valuable means of detecting subclinical disease that can benefit from modification of therapy. Furthermore, molecular studies reveal evidence of activity or progression not readily appreciated by histological techniques. Wider application is expected in multicenter clinical trials to predict and validate outcomes. The principal barrier to wider use of protocol biopsies is knowledge of the benefits of intervention.

Full Text

Duke Authors

Cited Authors

  • Mengel, M; Chapman, JR; Cosio, FG; Cavaillé-Coll, MW; Haller, H; Halloran, PF; Kirk, AD; Mihatsch, MJ; Nankivell, BJ; Racusen, LC; Roberts, IS; Rush, DN; Schwarz, A; Serón, D; Stegall, MD; Colvin, RB

Published Date

  • March 2007

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 512 - 517

PubMed ID

  • 17250556

Pubmed Central ID

  • 17250556

International Standard Serial Number (ISSN)

  • 1600-6135

Digital Object Identifier (DOI)

  • 10.1111/j.1600-6143.2006.01677.x


  • eng

Conference Location

  • United States